170886-13-2 | 2-(Trifluoromethyl)pyridin-4-ol

CAS:170886-13-2 | 2-(Trifluoromethyl)pyridin-4-ol ,Description

2-(Trifluoromethyl)pyridin-4-ol, also known as 2-TFMP, is an organic compound belonging to the pyridine family. It is a colorless liquid with a sweet odor and is soluble in water. It is used in a variety of applications, including in the synthesis of pharmaceuticals, agricultural chemicals, and other organic compounds. 2-TFMP has a wide range of biochemical and physiological effects, and its mechanism of action is still being studied. 
 

Scientific Research Applications

• Selective Metalation and Functionalization: Schlosser and Marull (2003) describe how 2-(trifluoromethyl)pyridine can be selectively metalated and subsequently functionalized at different positions, leading to the preparation of various pyridinecarboxylic acids and quinolinecarboxylic acids. This process is significant for creating building blocks in life-sciences-oriented research (Schlosser & Marull, 2003).
• Synthesis of (Trifluoromethoxy)pyridines: Manteau et al. (2010) achieved the synthesis of previously unknown (trifluoromethoxy)pyridines, which are valuable for life-sciences research. They also conducted the first X-ray crystallographic structure determinations for these compounds, enhancing our understanding of their molecular geometry (Manteau et al., 2010) .
• Reactivity with Pentafluoro- and Pentachloropyridine: Ranjbar‐Karimi et al. (2017) explored reactions of pyridin-2-ol, pyridin-3-ol, and pyridin-4-ol with pentafluoro- and pentachloropyridine. They found different reactivity patterns based on the position of the ol group, providing insights into nucleophilic behavior and structural confirmation via various spectroscopic methods (Ranjbar‐Karimi, Davodian, & Mehrabi, 2017) .
• Preparation of Trifluoromethyl-Substituted Pyridinecarboxylic Acids: In a study by Cottet, Marull, Lefebvre, and Schlosser (2003), strategies were developed for the preparation of trifluoromethyl-substituted pyridinecarboxylic acids, demonstrating the versatility of trifluoromethyl groups in synthesizing complex organic compounds (Cottet et al., 2003) .
• Displacement of Iodine by (Trifluoromethyl)copper: Another study by Cottet and Schlosser (2002) extended a method for creating trifluoromethyl substituted benzenes to pyridines, demonstrating the efficient conversion of iodopyridines to trifluoromethylpyridines (Cottet & Schlosser, 2002).

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