17129-06-5 | 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one

CAS:17129-06-5 | 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one ,Description

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one is an organic compound with the chemical formula C4H6F3O. It is a colorless liquid with a strong odor and is soluble in organic solvents. The compound is used as a precursor in the synthesis of various organic compounds, such as pharmaceuticals, pesticides, and fragrances. It is also used as a solvent in some industrial processes. The compound has been studied for its potential use in various scientific research applications.
 

Scientific Research Applications

• Synthesis of Trifluoromethylated Compounds: It is used for synthesizing trifluoromethylated spiro or fused cyclic compounds from 4-ethoxy-1,1,1-trifluoro-3-buten-2-one and silyl enol ethers (Jiang & Zhu, 2006).
• Peptide Synthesis: It acts as a protecting reagent in peptide synthesis, particularly for protecting the N-H terminal of amino acids without racemization (Gorbunova et al., 1991).
• Synthesizing Bis(trifluoroacetyl)ketene N,O-, N,S-, and S,S-acetals: It's useful in synthesizing these compounds and 2,2-Bis(trifluoroacetyl)vinylamines and sulfides (Hojo et al., 1992).
• Synthesis of Bicyclic Heterocycles: The chemical is used in the synthesis of trihalomethylated bicyclic heterocycles like isoxazoles and pyrazoles derivatives (Flores et al., 2005).
• Preparation of Trifluoromethyl Substituted Compounds: It assists in the preparation of trifluoromethyl substituted 2,3-dihydro-1,4-diazepine and benzimidazole (Chu et al., 2000).
• Synthesis of 4-trifluoroacetylpyrazoles: These synthesized compounds can be used for synthesizing various other compounds (Kamitori et al., 1993).
• Research in Cancer Drugs: The adducts formed by reacting 1,1,1-trifluoro-4-aryl-4-(N1-pyridine-2-carboxamidrazone)-3-buten-2-ones with copper(II) chloride are potential subjects for testing as anticancer drugs (Bonacorso et al., 2003).
• Diels-Alder Reactions: It's used in Diels-Alder reactions to prepare functionalized (trifluoromethyl)benzenes and -pyridines (Volle & Schlosser, 2002).
• Interaction with Various Compounds: 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one shows interaction with compounds like methylhydrazine, organomagnesium bromide, and organozinc compounds, leading to various substitution and addition products (Pavlik et al., 2002; Gorbunova et al., 1993; Zhao et al., 2010).
• Synthesis of Trifluoromethyl-Substituted Heteroarenes: It serves as a building block for the preparation of these compounds, including pharmaceuticals like Celebrex® (Sommer et al., 2017).

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