1717-59-5 | 2,2-Difluoro-2-(fluorosulfonyl)acetic acid

CAS:1717-59-5 | 2,2-Difluoro-2-(fluorosulfonyl)acetic acid ,Description

2,2-Difluoro-2-(fluorosulfonyl)acetic acid (DFSA) is a highly fluorinated organic acid that has become increasingly popular in scientific research due to its unique properties. DFSA has a wide range of applications in both organic and inorganic chemistry, including synthesis, catalysis, and biochemistry. It is also used in the synthesis of pharmaceuticals, agrochemicals, and other materials. DFSA is a versatile and powerful reagent, making it an attractive choice for many researchers. 
 

Scientific Research Applications

Difluorocarbene Generation

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate (MDFA) serves as an efficient source of difluorocarbene under specific conditions. It exhibits carbene reactivity comparable to trimethylsilyl 2,2-difluoro-2-(fluorosulfonyl)acetate (TFDA), generating difluorocyclopropane products (Eusterwiemann, Martínez, & Dolbier, 2012).

Interaction with Silver Oxide and Carbonate

The interaction of the sulfofluoride group in organofluorine compounds, including 2,2-difluoro-2-(fluorosulfonyl)acetic acid, with silver oxide and carbonate, is crucial in membrane, catalytic, and other advanced technologies. The synthesis of silver 2,2-difluoro-2(fluorosulfonyl)acetate demonstrates the consecutive utilization of sulfofluoride and fluorocarbonyl functions (Emel'yanov et al., 2011).

Anionotropic Transformations of β-Sultones

2,2-Difluoro-2-(fluorosulfonyl)acetic acid is involved in anionotropic transformations of β-sultones, leading to the preparation of various fluorine-containing esters and alkanoyl fluorides. This highlights its reactivity with nucleophilic reagents (Sokol'skii, Belaventsev, & Knunyants, 1970).

Introduction in Synthesis of Sulfur(VI) Fluorides

A crystalline, shelf-stable reagent [4-(acetylamino)phenyl]imidodisulfuryl difluoride (AISF) was developed for synthesizing sulfur(VI) fluorides, using difluorocarbene sources like 2,2-difluoro-2-(fluorosulfonyl)acetic acid for mild condition applications in the synthesis of aryl fluorosulfates and sulfamoyl fluorides (Zhou et al., 2018).

NMR Spectroscopic Studies

High-resolution NMR spectroscopy of difluoro(fluorosulfonyl) and difluoro(fluorosulfonyloxy) acetyl fluorides, including 2,2-difluoro-2-(fluorosulfonyl)acetic acid, has provided insights into complex spin-spin coupling mechanisms of fluorine and carbon nuclei (Emel'yanov et al., 2011).

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