174603-49-7 | 6-CHLORO-4-FLUORO-1-INDANONE

CAS:174603-49-7 | 6-CHLORO-4-FLUORO-1-INDANONE,Description

6-Chloro-4-fluoro-2,3-dihydro-1H-inden-1-one is a chemical compound with the molecular formula C9H6ClFO. It is a derivative of 1H-Inden-1-one, which is a bicyclic compound consisting of a benzene ring fused to a cyclopentene.

Synthesis Analysis

The synthesis of indanone derivatives, such as 6-Chloro-4-fluoro-2,3-dihydro-1H-inden-1-one, involves various methods. One common method is the cyclization of electron-rich 2-alkyl-1-ethynylbenzene derivatives. Other methods include the palladium-catalyzed carbonylative cyclization of unsaturated aryl iodides and dienyl triflates, iodides, and bromides.

Scientific Research Applications

Application 1: Antibacterial and Antifungal Studies

• Summary of the Application: 2,3-dihydro-1H-inden-1-one derivatives have been synthesized and studied for their antibacterial and antifungal properties.
• Methods of Application: A total of 15 derivatives from 2,3-dihydro-1H-inden-1-one were synthesized by grinding, stirring, and ultrasound irradiation methods.
• Results: The synthesized compounds were tested against two Gram-positive (Staphylococcus aureus and Bacillus subtilis) and two Gram-negative bacteria (Escherichia coli and Proteus vulgaris), and also two fungal agents (Aspergillus niger and Candida albicans). Most of the compounds were found to exert potent antibacterial action with broad-spectrum antibacterial activity.

Application 2: Antileishmanial Evaluation

• Summary of the Application: 2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-one derivatives, which are similar to 2,3-dihydro-1H-inden-1-one, have been evaluated for their antileishmanial activity.
• Methods of Application: The specific methods of application or experimental procedures were not detailed in the source.
• Results: In vivo antileishmanial evaluation of one of the derivatives demonstrated 56.2% inhibition in liver and 61.1% inhibition in spleen parasite burden in infected Balb/c mice.

Application 3: Antiviral Activity

• Summary of the Application: Indole derivatives, such as 6-Amino-4-substitutedalkyl-1H-indole-2-substitutedcarboxylate, have been reported as potential antiviral agents.
• Methods of Application: The specific methods of application or experimental procedures were not detailed in the source.
• Results: Compound methyl 6-amino-4-isobutoxy-1H-indole-2-carboxylate showed inhibitory activity against influenza A with IC50 = 7.53 μmol/L and the highest selectivity index (SI) value 17.1 to CoxB3 virus.

Application 4: Anticancer Activity

• Summary of the Application: Indole derivatives have been found to possess anticancer activity.
• Methods of Application: The specific methods of application or experimental procedures were not detailed in the source.
• Results: The results of the anticancer activity of indole derivatives were not detailed in the source.

Application 5: Antimalarial Activity 

• Summary of the Application: Quinoline derivatives, which are structurally similar to indole, have been used for a long time as a basic structure for the search of synthetic antimalarial drugs.
• Methods of Application: The specific methods of application or experimental procedures were not detailed in the source.
• Results: The results of the antimalarial activity of quinoline derivatives were not detailed in the source.

Application 6: Antihypertensive Activity

• Summary of the Application: Imidazole derivatives, which are structurally similar to indole, have been reported to show antihypertensive activity.
• Methods of Application: The specific methods of application or experimental procedures were not detailed in the source.
• Results: The results of the antihypertensive activity of imidazole derivatives were not detailed in the source.

Application 7: Antiobesity Activity

• Summary of the Application: Imidazole derivatives have also been reported to show antiobesity activity.
• Methods of Application: The specific methods of application or experimental procedures were not detailed in the source.
• Results: The results of the antiobesity activity of imidazole derivatives were not detailed in the source.

Safety And Hazards

The safety data sheet for 6-Chloro-4-fluoro-2,3-dihydro-1H-inden-1-one indicates that it may be harmful if swallowed, causes skin and eye irritation, and may cause respiratory irritation. The signal word for this compound is "Warning".

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