175278-12-3 | 4-Bromo-2-(trifluoromethoxy)iodobenzene

CAS:175278-12-3 | 4-Bromo-2-(trifluoromethoxy)iodobenzene ,Description

4-Bromo-2-(trifluoromethoxy)iodobenzene, also known as 4-bromo-2-trifluoromethoxyiodobenzene, is an organoiodine compound that is commonly used as a reagent in organic synthesis. It has a wide range of applications in research and industry, including the synthesis of pharmaceuticals, dyes, and other organic compounds. This compound is also used as a catalyst in organic reactions, such as the synthesis of polymers and other materials.
 

Scientific Research Applications

• Synthesis of Derivatives and Organic Transformations: 1,2-Dibromobenzenes, including derivatives like 1,2-Dibromo-3-iodobenzene and 1,2-dibromo-4-iodobenzene, are valuable precursors in various organic transformations, especially in reactions involving the formation of benzynes (Diemer, Leroux, & Colobert, 2011).
• Formation of Trifluoromethyl-Substituted Pyridines: 2-Iodopyridines can be converted into 2-(trifluoromethyl)pyridines almost quantitatively by displacement of iodide by (trifluoromethyl)copper generated in situ (Cottet & Schlosser, 2002).
• Generation of Arynes and Synthesis of Naphthalenes: Treatment of bromo-(trifluoromethoxy)benzenes with lithium diisopropylamide can generate intermediates that are useful for synthesizing naphthalenes and other organic compounds (Schlosser & Castagnetti, 2001).
• Coupling Reactions and Synthesis of Benzofurans: The CuI-catalyzed coupling of 1-bromo-2-iodobenzenes with beta-keto esters leads to the synthesis of 2,3-disubstituted benzofurans, involving intermolecular C-C bond formation and subsequent intramolecular C-O bond formation (Lu, Wang, Zhang, & Ma, 2007).
• Palladium-Catalyzed Trifluoroethylation: The palladium-catalyzed 2,2,2-trifluoroethylation of organoboronic acids and esters is an important transformation in medicinal chemistry and related fields. This process facilitates the introduction of fluorinated moieties into organic molecules, which can significantly alter their biological activities (Zhao & Hu, 2012).
• Bromolactonization of Alkenoic Acids: Iodobenzene, used as a recyclable catalyst with Oxone®, is effective in the bromolactonization of alkenoic acids, resulting in the formation of five-membered bromolactones (He, Pu, Shao, & Yan, 2011).

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