177469-12-4 | (R)-2-Amino-1,1,1-trifluoropropane hydrochloride

CAS:177469-12-4 | (R)-2-Amino-1,1,1-trifluoropropane hydrochloride ,Description

(R)-2-Amino-1,1,1-trifluoropropane hydrochloride, commonly known as trifluoromethyl-2-amino-1-propanol hydrochloride (TAP-HCl), is an organic compound that has recently gained attention in the scientific community due to its potential applications in laboratory experiments. TAP-HCl is a colorless, odorless, and non-toxic liquid that is soluble in water and other organic solvents. It is produced through a simple synthesis process and can be used in a variety of laboratory experiments. 
 

Scientific Research Applications

Efficient Synthesis

An efficient synthesis method for (R)-3-amino-1,1,1-trifluoropropan-2-ol, a compound closely related to (R)-2-Amino-1,1,1-trifluoropropane hydrochloride, has been developed, primarily for the large-scale production of a cholesterol ester transfer protein (CETP) inhibitor. This synthesis involves a modified Dakin–West reaction followed by asymmetric hydrogenation or enzymatic reduction, highlighting the compound's utility in the synthesis of medically relevant molecules (Wei et al., 2008) .

Chiral Building Blocks

The compound has been utilized in the preparation of chiral building blocks such as (R)- and (S)-3-Hydroxy-2-(trifluoromethyl)propionic Acid. This process involves the resolution with diols, demonstrating the compound's importance in creating enantiomerically pure chemicals for further research and application in various fields, including pharmaceuticals (CHIMIA, 1996).

Ionic Liquids

Research has also explored the preparation of highly-fluorinated triaminocyclopropenium salts, involving reactions with bis(2,2,2‐trifluoroethyl)amine. These compounds, with up to six fluorous groups, have been investigated for their properties as ionic liquids, suggesting potential applications in a variety of industrial and technological contexts (Curnow & Senthooran, 2022) .

Fluorinated Amino Acids

The palladium-catalyzed cross-coupling of unactivated alkylzinc reagents with 2-bromo-3,3,3-trifluoropropene, a related compound, has been developed as a key step in preparing trifluoromethylated and difluoromethylated amino acids. These amino acids are of significant interest in peptide/protein-based chemical biology, showcasing the compound's utility in the synthesis of biologically relevant molecules (Lou et al., 2019).

Antiproliferative Activity

Novel 2-amino-4-aryl-4,10-dihydro[1,3,5]triazino[1,2-a]benzimidazoles, synthesized from reactions involving 2-guanidinobenzimidazole and heteroaromatic aldehydes, have been investigated for their antiproliferative activity on various human cancer cell lines. This research indicates the potential application of the compound in the development of anticancer drugs (Hranjec et al., 2012).

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