17787-40-5 | Tetramethylammonium fluoride tetrahydrate

CAS:17787-40-5 | Tetramethylammonium fluoride tetrahydrate ,Description

Tetramethylammonium fluoride tetrahydrate (TMAF•4H2O) is an organic compound composed of four methyl groups, one ammonium group, and one fluoride ion. It is a white, water-soluble solid that is used in a variety of laboratory applications. TMAF•4H2O has a wide range of uses in the fields of organic synthesis, medicinal chemistry, and analytical chemistry. It can be used as a reagent or catalyst in a variety of reactions, such as the synthesis of drugs, polymers, and other materials. Additionally, it can be used as a chelating agent in analytical chemistry and as a biocompatible material in medical applications. 
 

Scientific Research Applications

Selective Methylation of Organic Compounds

Tetramethylammonium fluoride (TMAF) serves as a selective methylating agent for a variety of organic compounds including amides, indoles, pyrroles, imidazoles, alcohols, and thiols. The process is noted for its operational simplicity, broad applicability, and easy purification steps, making TMAF a versatile reagent in organic synthesis (Hong‐Gang Cheng et al., 2019).

Biaryl Coupling

TMAF is instrumental in promoting the coupling of aryl iodides with unactivated arenes to form biaryls. This method, which does not require strong bases or expensive additives, can be conducted in air and moisture without specific precautions, offering a versatile approach to synthesizing aromatic and heteroaromatic compounds (Kanako Nozawa‐Kumada et al., 2019) .

Utilization in Material Science and Environmental Studies

Perovskite Solar Cells

In the realm of solar energy, TMAF is used to modify the surface and electrical properties of electrodes in perovskite solar cells, improving their efficiency and reducing certain performance issues. This application highlights the role of TMAF in advancing renewable energy technologies (Chun Huang et al., 2019).

Gas Sensing Technologies

TMAF-coated quartz crystals have been employed to quantify gases like CO2, SO2, NH3, and H2S. This demonstrates the potential of TMAF in developing sensitive and stable sensors for environmental monitoring (M. Gomes et al., 2000).

Fundamental Studies and Innovative Applications

Molecular Orbital Studies

The infrared spectrum and molecular structure of TMAF have been a subject of interest, particularly in understanding the strong C–H⋯F − hydrogen bonds and their potential effects on solid-state structure. These studies contribute to the fundamental understanding of molecular interactions and material properties (K. Harmon & Susan L. Madeira, 2001) .

Photocatalytic Degradation

In exploring the modification of surface functional groups of photocatalysts, TMAF has been used to study the photocatalytic degradation of tetramethylammonium ions. This work helps in understanding how surface modifications can influence photocatalytic activities, with implications for environmental cleanup technologies (Muhammad Shariq Vohra et al., 2003).

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