18063-03-1 | 2,6-Difluorobenzamide

CAS:18063-03-1 | 2,6-Difluorobenzamide ,Description

2,6-Difluorobenzamide (2,6-DFBA) is an organic compound that is widely used in scientific research and various applications. It is a fluorinated aromatic amide that is colorless, crystalline, and water-soluble. It is used as a building block in organic synthesis, as a reagent for a variety of chemical reactions, and as a tool for studying biochemical and physiological effects. 2,6-DFBA has been widely studied due to its versatility, and it has many advantages and limitations for use in laboratory experiments. In 
 

Scientific Research Applications

Synthesis and Production

2,6-Difluorobenzamide is synthesized from 2,6-dichlorobenzonitrile through various methods, including fluorination and hydrolysis, with an emphasis on high yield and environmental friendliness. For example, one study achieved a product yield of 80.5% and a melting point of 145.4-145.6°C, highlighting the efficiency of the process (Li Xiu-lian, 2009). Another approach utilized recombinant Escherichia coli expressing nitrile hydratase for efficient production, optimizing parameters like temperature and substrate loading for high yields (Zhengfei Yang et al., 2018).

Environmental Impact and Alternative Methods

Research has focused on reducing environmental impact in the production of 2,6-Difluorobenzamide. One study explored a green preparation technology through non-catalytic hydrolysis in high-temperature liquid water, providing a less pollutive method (Ren Haoming, 2011). Another technique involved using resting cells of Rhodococcus ruber for chemoselective biocatalytic hydrolysis, emphasizing its high yield and environmental friendliness (Rui Tang et al., 2017).

Role in Antibacterial Research

2,6-Difluorobenzamide derivatives have been investigated for their antibacterial properties. Studies have focused on modifying its structure to enhance its potency against bacteria like Staphylococcus aureus. For example, the introduction of a 1,4-benzodioxane-2-methyl residue resulted in potent antistaphylococcal compounds (G. Chiodini et al., 2015). In a similar vein, research has delved into the synthesis of novel 2,6-difluorobenzamide derivatives to inhibit bacterial cell division, showing promising antibacterial activity (Fangchao Bi et al., 2017).

Molecular and Structural Analysis

The molecular and structural properties of 2,6-Difluorobenzamide and its derivatives have been extensively studied. Investigations include conformational analysis, molecular docking, and exploring the impact of fluorination on molecular interactions and activity against bacteria (Thibaut Barbier et al., 2023). Understanding these aspects is crucial for developing more effective antibacterial agents.

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