193353-34-3 | 2,5-DIFLUOROPHENYLBORONIC ACID

CAS:193353-34-3 | 2,5-DIFLUOROPHENYLBORONIC ACID,Description

Synthesis Analysis

The synthesis of related boronic acids often involves catalytic processes that utilize boronic acids as key intermediates. For instance, perfluorophenylboronic acids have been used in the direct stereoselective synthesis of 2-deoxygalactosides, showcasing the role of boronic acids in facilitating complex glycosylation reactions without the need for metal catalysts or excess nucleophiles (Tatina et al., 2019).

Molecular Structure Analysis

The molecular structure of difluorophenylboronic acids has been investigated through various spectroscopic techniques. In one study, 2,3-difluorophenylboronic acid was characterized using FT-IR, FT-Raman, UV-Vis, and NMR spectroscopy, combined with quantum chemical calculations, revealing insights into its conformers and molecular vibrations (Karabacak et al., 2012).

Chemical Reactions and Properties

Boronic acids, including difluorophenylboronic acids, play a crucial role in organic synthesis, particularly in coupling reactions. The Suzuki-Miyaura reaction is a notable example where boronic acids act as coupling partners to form biaryl compounds. This reaction has been optimized for challenging substrates like polyfluorophenylboronic acids, highlighting the adaptability and utility of boronic acids in cross-coupling chemistry (Kinzel et al., 2010).

Scientific Research Applications

2,5-Difluorophenylboronic Acid is a biochemical reagent. It’s often used in scientific research, particularly in the field of organic chemistry. Here are some of its applications:

• Suzuki-Miyaura Cross-Coupling Reaction : This is a type of palladium-catalyzed cross-coupling reaction used to synthesize carbon-carbon bonds. 2,5-Difluorophenylboronic Acid is used as a reagent in this reaction. The specific methods of application or experimental procedures would depend on the particular reaction being carried out. The outcomes of these reactions are typically new organic compounds, the properties of which would depend on the specific reactants used.
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• Fluorination Reagents : Fluorination is a process used in organic chemistry to introduce fluorine into a compound. 2,5-Difluorophenylboronic Acid, being a fluorinated compound, could potentially be used as a fluorination reagent. The specific methods of application and outcomes would depend on the particular reaction being carried out.
• Fluorinated Building Blocks : Fluorinated compounds are often used as building blocks in the synthesis of more complex organic compounds. 2,5-Difluorophenylboronic Acid, being a fluorinated compound, could potentially be used as such a building block. The specific methods of application and outcomes would depend on the particular synthesis being carried out.
• Preparation of Selective Sphingosine Phosphate Receptor Antagonists : 2,5-Difluorophenylboronic Acid can be used as a reagent for the preparation of potent and selective sphingosine phosphate receptor antagonists. These antagonists function as therapeutic agents for the treatment of influenza infections. The specific methods of application and outcomes would depend on the particular synthesis being carried out.
• Laboratory Chemicals : 2,5-Difluorophenylboronic Acid can be used in the production of laboratory chemicals. It could potentially be used in a variety of chemical reactions and syntheses. The specific methods of application and outcomes would depend on the particular reaction or synthesis being carried out.
• Kinetic Analysis : 2,5-Difluorophenylboronic Acid can be used in kinetic analysis of competition conducted between different boron reagents. The boronic acid was found to be the most reactive species even when its proportion was very small. The specific methods of application and outcomes would depend on the particular reaction being carried out.
• Laboratory Chemicals Production : 2,5-Difluorophenylboronic Acid can be used in the production of various laboratory chemicals. It could potentially be used in a variety of chemical reactions and syntheses. The specific methods of application and outcomes would depend on the particular reaction or synthesis being carried out.

Safety And Hazards

2,5-Difluorophenylboronic acid is considered hazardous according to the 2012 OSHA Hazard Communication Standard. It can cause skin corrosion/irritation and serious eye damage/eye irritation. It can also cause specific target organ toxicity (single exposure), with the respiratory system being a target organ.

Future Directions

2,5-Difluorophenylboronic acid has potential applications in the development of therapeutic agents for the treatment of influenza infections. Its use in Suzuki-Miyaura cross-coupling reactions also suggests potential applications in the synthesis of various organic compounds.

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