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Purchase CAS:202865-60-9 | 4-Bromo-2,5-difluoroanisole,view related peer-reviewed papers,technical documents,similar products,MSDS & more.Synthesis AnalysisThe synthesis of related brominated compounds is detailed in several papers. For instance, the synthesis of 4-chloro-2,5-difluorobenzoic acid from 2,5-difluoroaniline involves a Sandmeyer reaction, followed by bromination and a Grignard reaction, with specific conditions leading to...
The synthesis of related brominated compounds is detailed in several papers. For instance, the synthesis of 4-chloro-2,5-difluorobenzoic acid from 2,5-difluoroaniline involves a Sandmeyer reaction, followed by bromination and a Grignard reaction, with specific conditions leading to a high purity product. Similarly, the synthesis of bromofluorinated alkenes is described, starting with the addition of bromine to chlorotrifluoroethylene. These methods could potentially be adapted for the synthesis of 4-Bromo-2,5-difluoroanisole by substituting the appropriate starting materials and adjusting reaction conditions.
The molecular structure of brominated compounds can be complex, as demonstrated by the X-ray crystallography studies of bis(pyridine)bromonium triflate and bis(2,4,6-collidine)bromonium perchlorate. These studies reveal the formation of unstable intermediates and the importance of molecular geometry in the reactivity of brominated species. The crystal structures of dihydrogen hexafluorosilicate monohydrates of brominated anilines also provide insights into the arrangement of brominated aromatic compounds.
The reactivity of brominated compounds with various acceptors is discussed, with mechanisms involving dissociation to form unstable intermediates and direct nucleophilic attacks. The copolymerization of vinylidene fluoride with brominated monomers and the subsequent chemical modifications of the resulting polymers are also explored. These studies suggest that 4-Bromo-2,5-difluoroanisole could undergo similar reactions, potentially leading to a variety of derivatives and applications.
While the physical and chemical properties of 4-Bromo-2,5-difluoroanisole are not directly reported, the properties of related compounds can be inferred. For example, the continuous, homogeneous, and rapid synthesis of 4-bromo-3-methylanisole in a microreaction system indicates that similar brominated anisoles can be synthesized with high selectivity and purity under controlled conditions. The regiospecific allylic bromination of trihaloalkenones and their applications in heterocyclic synthesis also highlight the versatility of brominated compounds in organic synthesis.
Case studies involving the synthesis and reactivity of brominated compounds are prevalent throughout the papers. The synthesis of 1-bromo-4,4,4-trifluoro-3-(trifluoromethyl)but-2-ene and its electrophilic reactivity with various nucleophiles is one such example, demonstrating the potential for creating a diverse array of substituted products. The preparation of 1,3-dibromo-1,1-difluoro-2-propanone and its use in the synthesis of thiazoles is another case study that showcases the utility of brominated synthons in drug discovery. These examples provide a framework for understanding how 4-Bromo-2,5-difluoroanisole might be synthesized and utilized in various chemical transformations.
4-Bromo-2,5-difluoroanisole may cause skin irritation, serious eye irritation, and respiratory irritation. It is recommended to avoid breathing its dust, fume, gas, mist, vapors, or spray. Protective measures such as wearing gloves, protective clothing, eye protection, and face protection are advised.
$2.00 / 1kg 2019-07-06 CAS:202865-60-9 Min. Order: 1kg Purity: 99% Supply Ability: 100kg
4-Bromo-2,5-difluoroanisole Basic information |
Product Name: | 4-Bromo-2,5-difluoroanisole |
Synonyms: | 4-BROMO-2,5-DIFLUOROANISOLE;4-Bromo-2,5-difluoroanisole 99%;4-Bromo-2,5-difluoroanisole99%;1-Bromo-2,5-difluoro-4-methoxybenzene;4-Bromo-2,5-difluoroanisole,98%;4-Bromo-2,5-difluoroanisole Basic information;4-Bromo-2,5-difluoroznisole;4-Bromo-2,5-difluoroanisole > |
CAS: | 202865-60-9 |
MF: | C7H5BrF2O |
MW: | 223.01 |
EINECS: | 606-491-3 |
Product Categories: | Aromatic Ethers;Anisole;Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;Fluorine Compounds |
Mol File: | 202865-60-9.mol |
4-Bromo-2,5-difluoroanisole Chemical Properties |
Melting point | 59-63 °C |
Boiling point | 200.7±35.0 °C(Predicted) |
density | 1.615±0.06 g/cm3(Predicted) |
form | Crystals |
color | White to off-white |
CAS DataBase Reference | 202865-60-9(CAS DataBase Reference) |