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“(2,4,6-Trifluorophenyl)methanamine” is a chemical compound with the molecular formula C7H6F3N.
The synthesis of “(2,4,6-Trifluorophenyl)methanamine” involves several steps. The raw material is processed under reduced pressure to recover the solvent. The residue is then treated with dichloromethane and cooled to 0-5 °C with an ice bath. The pH is adjusted to about 10 with liquid caustic, and the organic phase is separated. The organic phase is dried with anhydrous sodium sulfate.
The molecular structure of “(2,4,6-Trifluorophenyl)methanamine” is represented by the InChI code 1S/C7H6F3N/c8-4-1-6(9)5(3-11)7(10)2-4/h1-2H,3,11H2
. The molecular weight of this compound is 161.13.
“(2,4,6-Trifluorophenyl)methanamine” is a solid or liquid at room temperature. It should be stored in a refrigerator and kept in a dark place under an inert atmosphere.
(4-Phenylquinazolin-2-yl)methanamine, a derivative of (2,4,6-Trifluorophenyl)methanamine, has been synthesized from glycine and used in N-heterocyclic ruthenium(II) complexes. These complexes have demonstrated excellent efficiency as catalysts in transfer hydrogenation of acetophenone derivatives, achieving up to 99% conversions and high turnover frequency values (Karabuğa et al., 2015) .
A series of functionalized mono-, bis- and tris-(S)-{(2S,4R,8R)-8-ethyl-quinuclidin-2-yl}methanamines, including derivatives of (2,4,6-Trifluorophenyl)methanamine, were synthesized and investigated for in vitro antitumor activity. These compounds showed notable cytotoxicity and cytostatic effects on various human cancer cell lines, indicating potential as antitumor agents (Károlyi et al., 2012) .
In an environmental context, studies on 2,4,6-Trichlorophenol, a compound related to (2,4,6-Trifluorophenyl)methanamine, have been conducted to derive predicted no-effect concentrations (PNEC) for aquatic environments. These studies are crucial for assessing the environmental impact and safety of chemical compounds (Jin et al., 2012).
Research has been conducted on new palladium (Pd)II and platinum (Pt)II complexes using Schiff base ligands derived from (2,4,6-Trifluorophenyl)methanamine. These complexes have shown promising anticancer activity against various human cancer cell lines, opening avenues for their potential use in cancer treatment (Mbugua et al., 2020).
Certain derivatives of (2,4,6-Trifluorophenyl)methanamine have been synthesized and evaluated for their antibacterial and antifungal activities. These compounds have displayed moderate to very good activities against pathogenic strains, highlighting their potential in pharmaceutical applications (Thomas et al., 2010).
Studies on ligands derived from (2,4,6-Trifluorophenyl)methanamine have shown unique photophysical behaviors. These properties are essential in chemical analysis and could potentially be used in sensing and detection technologies (Ping-hua, 2010).
“(2,4,6-Trifluorophenyl)methanamine” is associated with several hazards. It can cause severe skin burns and eye damage. The compound has been assigned the GHS07 pictogram, and the associated hazard statements are H302, H315, H319, and H335. Precautionary measures include avoiding breathing dust/fume/gas/mist/vapours/spray, washing hands thoroughly after handling, and wearing protective gloves/clothing/eye protection/face protection.
Product Name: | 2,4,6-TRIFLUOROBENZYL AMINE |
Synonyms: | RARECHEM AL BW 0429;2,4,6-TRIFLUOROBENZYL AMINE;Benzenemethanamine, 2,4,6-trifluoro- (9CI);1-(2,4,6-Trifluorophenyl)methylamine;2,4,6-trifluorobenzylaminine;(2,4,6-Trifluorophenyl)methylamine;Benzenemethanamine, 2,4,6-trifluoro-;Chlorfenvinphos Impurity 7 |
CAS: | 214759-21-4 |
MF: | C7H6F3N |
MW: | 161.12 |
EINECS: | |
Product Categories: | Fluorine series;HALIDE;214759-21-4 |
Mol File: | 214759-21-4.mol |
2,4,6-TRIFLUOROBENZYL AMINE Chemical Properties |
Boiling point | 165℃ |
density | 1.320 |
Fp | 63℃ |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 8.16±0.10(Predicted) |
form | liquid |
color | Colourless |
Water Solubility | Slightly Soluble in water (1.2 g/L) (25°C). |
Sensitive | Air Sensitive |
Stability: | Air Sensitive |