2167095-52-3 | 3,3-Difluoro-1-(trifluoromethyl)cyclobutane-1-carboxylic acid

CAS:2167095-52-3 | 3,3-Difluoro-1-(trifluoromethyl)cyclobutane-1-carboxylic acid ,Description

3,3-Difluoro-1-(trifluoromethyl)cyclobutane-1-carboxylic acid, also known as DFCA, is a fluorinated cyclobutane derivative that has gained significant attention in the field of medicinal chemistry. This compound has been studied extensively for its potential therapeutic applications due to its unique chemical properties.
 

Scientific Research Applications

Synthesis and Derivatives

Trifluoromethyl-substituted analogues of 1-amino-cyclobutane-1-carboxylic acid have been synthesized, highlighting the chemical versatility of this compound. The key step in these syntheses involves the transformation of the acid moiety into the trifluoromethyl group using SF4 and HF (Radchenko et al., 2009). Furthermore, multigram synthesis of 3,3-difluorocyclobutyl-substituted building blocks, including carboxylic acid, demonstrates the compound's potential in creating a variety of chemical derivatives (Ryabukhin et al., 2018).

Medical Imaging Applications

3,3-Difluoro-1-(trifluoromethyl)cyclobutane-1-carboxylic acid and its derivatives have been explored in medical imaging. For instance, fluorine-18 labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC) has been synthesized for use in positron emission tomography (PET), a critical tool in tumor delineation (Shoup & Goodman, 1999). Additionally, syn- and anti-1-amino-3-[18F]fluoromethyl-cyclobutane-1-carboxylic acid (FMACBC) analogues have shown promising results in imaging brain tumors (Martarello et al., 2002).

Chemical Transformations

The deoxyfluorination of carboxylic acids to produce various acyl fluorides using 3,3-difluoro-1,2-diphenylcyclopropene as a reagent showcases the compound's role in facilitating diverse chemical transformations (Wang et al., 2021).

Structural Studies

The compound's structure and conformations have been analyzed, as in the case of cis-2-phenylcyclobutanecarboxylic acid and cis-3-(p-fluorophenyl)cyclobutanecarboxylic acid, providing insights into its molecular geometry and potential applications in material science or drug design (Reisner et al., 1983).

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