22123-14-4 | 2-Chloro-6-methyl-4-(trifluoromethyl)pyridine

CAS:22123-14-4 | 2-Chloro-6-methyl-4-(trifluoromethyl)pyridine,Description

2-Chloro-6-methyl-4-(trifluoromethyl)pyridine, or 2C6M4TFP, is an organic compound with a molecular formula of C7H5ClF3N. It is a colorless liquid and has a pungent odor. It is an important intermediate for the production of pharmaceuticals and agrochemicals. It is also used in the synthesis of a variety of organic compounds and as a catalyst for certain chemical reactions.
 

Scientific Research Applications

Halogen Shuffling and Electrophilic Substitutions

2-Chloro-6-(trifluoromethyl)pyridine exhibits interesting behavior in reactions involving halogen shuffling and electrophilic substitutions. A study by Mongin et al. (1998) explored this by treating the compound with lithium diisopropylamide and iodine, converting it into its 3-iodo derivative. This derivative can be isomerized to 2-chloro-4-iodo-6-(trifluoromethyl)pyridine, which is a useful starting material for further chemical manipulations involving halogen/metal exchange and electrophilic trapping (Mongin et al., 1998).

Synthesis of Pesticides

The compound is also significant in the synthesis of pesticides. Lu Xin-xin (2006) reviewed various processes for synthesizing 2,3-dichloro-5-trifluoromethyl pyridine, a closely related compound, highlighting its widespread use in pesticide synthesis (Lu Xin-xin, 2006).

Logistic Flexibility in Synthesizing Carboxylic Acids

Another application involves the preparation of isomeric halopyridinecarboxylic acids. Cottet and Schlosser (2004) demonstrated the straightforward preparation of specific carboxylic acids from 2-chloro-4-(trifluoromethyl)pyridine, showcasing the compound's versatility and logistical flexibility in organic synthesis (Cottet & Schlosser, 2004).

Antimicrobial Activities and Structural Properties

The antimicrobial activities and structural properties of 2-chloro-6-(trifluoromethyl)pyridine have also been investigated. Evecen et al. (2017) conducted a study analyzing its molecular structure and antimicrobial properties, including its interactions with DNA, demonstrating its potential in the field of biochemistry and pharmaceutical research (Evecen et al., 2017).

Application in Herbicides

Li Zheng-xiong (2004) summarized the synthetic methods for 2-chloro-5-trifluoromethyl pyridine, a variant of the compound , and discussed its applications as an intermediate in herbicides, pharmaceuticals, and biochemicals. This study highlights the compound's significant role in various industrial applications (Li Zheng-xiong, 2004).

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