2240-88-2 | 3,3,3-Trifluoro-1-propanol

CAS:2240-88-2 | 3,3,3-Trifluoro-1-propanol ,Description

3,3,3-Trifluoro-1-propanol, commonly referred to as TFP, is an organic compound composed of three fluorine atoms and one hydrogen atom. It is a colorless liquid at room temperature and has a boiling point of 118°C and a melting point of -70°C. It is a versatile compound with a wide range of applications in both industry and scientific research. 
 

Scientific Research Applications

Electrophilic Reagent in Synthesis

3,3,3-Trifluoro-1-propanol has been utilized in the design and synthesis of hypervalent trifluoromethylthio-iodine(III) reagents. These compounds serve as versatile electrophilic reagents for transferring the trifluoromethylthio group (-SCF3) to various nucleophiles. The study conducted by Xiao-Guang Yang et al. (2020) explored its hydrogen-bonding mode for activation by the solvent 1,1,1,3,3,3-hexafluoro-2-propanol, highlighting the reagent's broad applicability in synthetic chemistry (Yang, Zheng, & Zhang, 2020).

Chemical Fixation of CO2

Another significant application of trifluoropropanol derivatives is in the chemical fixation of CO2 with epoxides to produce cyclic carbonates. A study led by Huiyong Ma et al. (2020) found that 3-Bromo-1,1,1-trifluoro-2-propanol, in combination with n-butylammonium iodide (TBAI), acts as an efficient organocatalyst for this reaction. This process, which is enhanced by hydrogen bonding, showcases the potential of trifluoropropanol derivatives in green chemistry and CO2 sequestration efforts (Ma, Zeng, Tu, Mao, Zhao, Wang, Liu, & Lu, 2020).

Conformational and Spectroscopic Studies

The conformational landscapes of partially fluorinated carboxylic acids, including 3,3,3-trifluoro-2-(trifluoromethyl)propanoic acid, have been explored through high-resolution spectroscopic studies. This research provides insights into the structural and energetic preferences of such molecules, contributing to the understanding of their behavior in various chemical environments. The findings from studies conducted by Javix Thomas et al. (2016) offer a foundation for designing more effective fluorinated compounds in various applications (Thomas, Carrillo, Serrato, Schnitzler, Jäger, Xu, & Lin, 2016).

Photodissociation Dynamics

Research on the photodissociation dynamics of bromo and trifluoro propanol derivatives, such as 3-bromo-1,1,1-trifluoro-2-propanol, has provided valuable data on the behavior of these molecules under UV radiation. Studies by Yogesh N. Indulkar et al. (2011) delve into the molecular processes involved in the C-Br bond dissociation, contributing to a deeper understanding of the photochemical properties of fluorinated alcohols (Indulkar, Saha, Upadhyaya, Kumar, Waghmode, Naik, & Bajaj, 2011).

More Information