22419-35-8 | 4,4-Difluorocyclohexanol

CAS:22419-35-8 | 4,4-Difluorocyclohexanol ,Description

4,4-Difluorocyclohexanol (DFC) is a synthetic organic compound belonging to the cyclohexanol group of alcohols. It is a colorless liquid with a faint odor and a melting point of -21°C. It is a versatile compound and has been used extensively in scientific research, laboratory experiments, and industrial applications.
 

Scientific Research Applications

1. Nuclear Waste Treatment and Sensor Development

4,4’-[di t-butyldibenzo]-18-crown-6 and its cyclohexanol-based derivative are used for selective metal ion extraction. This property is particularly beneficial in areas like nuclear waste treatment and the development of sensors. These substances can efficiently separate specific metal ions from mixtures, which is crucial in handling nuclear waste and creating sensitive detection systems for various ions (Dutta et al., 2022).

2. Conformational Studies in Chemistry

The conformational equilibria of molecules like 4,4-difluorocyclohexanol are studied using techniques such as fluorine and proton NMR. These studies are significant in understanding the molecular structures and interactions in polar flexible molecules, which can have applications in designing drugs and other chemical products (Stolow et al., 1968).

3. Organocatalysis in Asymmetric Synthesis

Polystyrene-immobilized pyrrolidine, a catalyst developed for the Michael addition of cyclohexanone to nitroolefins, showcases the importance of cyclohexanol derivatives in asymmetric synthesis. These compounds play a crucial role in achieving high yields and selectivity in reactions that are fundamental to producing various pharmaceuticals and fine chemicals (Miao & Wang, 2008).

4. Bioorganic Reagents and Enzyme Catalysis

Cyclohexanone derivatives are used to study enzyme catalysis, particularly in the field of bioorganic chemistry. For example, mutants of cyclohexanone monooxygenase have been investigated for their catalytic capabilities and selectivity, providing insights into enzyme behavior and potential applications in biotransformations (Kayser & Clouthier, 2006).

5. Advanced Materials and Polymer Science

Research involving 4,4-difluorocyclohexanol contributes to the development of advanced materials, particularly in polymer science. For instance, studies on polyesters synthesized from furandicarboxylic acid and cyclohexanedimethanol show that these materials have potential as bio-based engineering plastics. The properties of these polyesters, such as crystallinity and thermal stability, are directly influenced by the steric configuration of cyclohexanol derivatives (Wang et al., 2018).

More Information