2356-16-3 | Triethyl 2-fluoro-2-phosphonoacetate

CAS:2356-16-3 | Triethyl 2-fluoro-2-phosphonoacetate ,Description

Triethyl 2-fluoro-2-phosphonoacetate (TEFP) is an organofluorophosphate compound used in various scientific research applications, including as a reagent in organic synthesis, as a catalyst in enzymatic reactions, and as a substrate for biochemical and physiological studies. TEFP is a colorless liquid with a molecular weight of 202.06 g/mol and a boiling point of 99.5 °C. TEFP has been used in many areas of research, including drug development, biochemistry, and enzymology.
 

Scientific Research Applications

Triethyl 2-fluoro-2-phosphonoacetate has been used in many areas of scientific research, including drug development, biochemistry, and enzymology. In drug development, Triethyl 2-fluoro-2-phosphonoacetate has been used as a substrate for the enzymatic synthesis of various drugs, such as the anticoagulant warfarin. In biochemistry, Triethyl 2-fluoro-2-phosphonoacetate has been used as a reagent in the synthesis of other organofluorophosphates, such as phosphoramidates and phosphonates. In enzymology, Triethyl 2-fluoro-2-phosphonoacetate has been used as a substrate for the study of enzyme-catalyzed reactions, such as the hydrolysis of peptides and proteins.
 

Mechanism of Action

Triethyl 2-fluoro-2-phosphonoacetate acts as a substrate for enzymes, meaning that it is the molecule that is acted upon by the enzyme. When Triethyl 2-fluoro-2-phosphonoacetate is present in an enzymatic reaction, the enzyme binds to it and catalyzes a reaction that results in the formation of a new product. The mechanism of action of Triethyl 2-fluoro-2-phosphonoacetate depends on the type of enzyme that it is interacting with. For example, when Triethyl 2-fluoro-2-phosphonoacetate is used as a substrate for the hydrolysis of peptides and proteins, the enzyme catalyzes the hydrolysis of the peptide or protein into smaller peptides or amino acids.
 

Biochemical and Physiological Effects

Triethyl 2-fluoro-2-phosphonoacetate has been used in various biochemical and physiological studies, including studies of its effects on cells. In cell-based studies, Triethyl 2-fluoro-2-phosphonoacetate has been found to inhibit the growth of certain types of cancer cells, as well as to induce apoptosis in these cells. Triethyl 2-fluoro-2-phosphonoacetate has also been found to modulate the expression of certain genes, which may be involved in the regulation of cell proliferation and differentiation. In addition, Triethyl 2-fluoro-2-phosphonoacetate has been found to modulate the activity of certain enzymes, such as those involved in the metabolism of glucose.
 

Advantages and Limitations for Lab Experiments

Triethyl 2-fluoro-2-phosphonoacetate has several advantages when used in laboratory experiments, including its low cost, low toxicity, and compatibility with a variety of chemicals and other substances. Triethyl 2-fluoro-2-phosphonoacetate is also relatively stable in solution, making it suitable for use in long-term experiments. However, Triethyl 2-fluoro-2-phosphonoacetate has certain limitations, including its relatively low solubility in water and its susceptibility to hydrolysis.
 

Future Directions

There are many potential future directions for the use of Triethyl 2-fluoro-2-phosphonoacetate in scientific research. One potential direction is the use of Triethyl 2-fluoro-2-phosphonoacetate as a substrate for the synthesis of other organofluorophosphates, such as phosphoramidates and phosphonates. Another potential direction is the use of Triethyl 2-fluoro-2-phosphonoacetate in drug development, as a substrate for the enzymatic synthesis of various drugs. Additionally, Triethyl 2-fluoro-2-phosphonoacetate could be used in the study of enzyme-catalyzed reactions, such as the hydrolysis of peptides and proteins. Finally, Triethyl 2-fluoro-2-phosphonoacetate could be explored as a potential therapeutic agent, as it has been found to have anti-cancer and anti-inflammatory properties.

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