2377-81-3 | Tetrafluoroisophthalonitrile

CAS:2377-81-3 | Tetrafluoroisophthalonitrile ,Description

Tetrafluoroisophthalonitrile (TFIPN) is an organic compound with the chemical formula C8H2F4N2. It is a colorless liquid, with a boiling point of 124°C and a melting point of -46°C. TFIPN is a versatile and useful compound that has been studied for its potential applications in scientific research, lab experiments, and industrial processes.
 

Scientific Research Applications

Trifluoromethylation of Aromatic Materials

Tetrafluoroisophthalonitrile has been used in trifluoromethylation of activated aromatic materials, using the CF3TMS–CuI–KF system. This application is significant for constructing di- and/or tri-trifluoromethylated benzonitriles through decyanotrifluoromethylation (Kitazume & Nakajima, 2004).

Charge Density Studies

Tetrafluoroisophthalonitrile has been a subject in the study of experimental electron density distributions (EDD), utilizing X-ray diffraction data. This research is crucial for understanding the topological analysis of electron density and the molecular electrostatic potential of such compounds (Hibbs et al., 2004).

Synthesis of Aromatic Polyethers

The phase-transfer catalyzed polycondensation of tetrafluoroisophthalonitrile with various bisphenols has led to the synthesis of new aromatic polyethers. These polymers, characterized by their high thermal stability and solubility, are used to cast transparent and flexible films (Shimizu, Kakimoto, & Imai, 1987).

Covalent Organic Frameworks

Tetrafluoroisophthalonitrile has been utilized in creating crystalline covalent organic frameworks (COFs), linked through 1,4-dioxin linkages. These COFs, formed by irreversible reactions, exhibit high chemical stability, opening avenues for various post-synthetic modifications and applications (Zhang et al., 2018).

Preparation of Fluorinated Isoindoles and Benzoporphyrins

Research on tetrafluoroisophthalonitrile includes its role in the preparation of fluorinated isoindoles and their conversion to fluorinated benzoporphyrins. These compounds have potential applications in various fields including materials science and pharmaceuticals (Uno et al., 2007).

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