2516-99-6 | 3,3,3-Trifluoropropionic acid

CAS:2516-99-6 | 3,3,3-Trifluoropropionic acid ,Description

3,3,3-Trifluoropropionic acid, also known as TFPA, is a colorless liquid with a pungent odor. It is a carboxylic acid that is widely used in various scientific and industrial applications. It is an important intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. TFPA is also used as a solvent in chemical synthesis and as a reagent in organic synthesis.
 

Scientific Research Applications

Microwave Spectrum Analysis

The rotational spectrum of 3,3,3-trifluoropropionic acid was measured using supersonic jet chirped-pulse Fourier transform microwave spectroscopy. This study provides valuable data on the molecule's structure and properties, aiding further research in molecular spectroscopy and related fields (Evangelisti & Wijngaarden, 2013).

Environmental Fate Analysis

Research on the aerobic defluorination of short-chain fluorinated carboxylic acids, including 3,3,3-trifluoropropionic acid, by activated sludge communities highlights its environmental impact. This study enhances the understanding of the environmental fate of per- and polyfluoroalkyl substances (PFAS), contributing to the development of more effective chemical-biological PFAS treatment systems (Che et al., 2021).

Synthetic Chemistry Applications

In synthetic chemistry, 3,3,3-trifluoropropionic acid has been utilized in various reactions. Its use in boron-mediated enolization-aldolization represents a significant advancement in the synthesis of specific organic compounds (Ramachandran et al., 2010). Furthermore, the stereoselective synthesis of 3-fluoro-2-alkenoic acids and other fluorinated compounds using 3,3,3-trifluoropropionic acid showcases its versatility in the creation of biologically active chemicals (Xiao & Kitazume, 1997).

Use in LC/ESI-MS

Partially fluorinated carboxylic acids, such as 3,3,3-trifluoropropionic acid, are utilized as ion-pairing reagents in high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (LC/ESI-MS). This application is critical for the analysis of basic analytes and represents a significant methodological advancement in analytical chemistry (Yamamoto et al., 2014).

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