2730-62-3 | 2-Chloro-3,3,3-trifluoroprop-1-ene

CAS:2730-62-3 | 2-Chloro-3,3,3-trifluoroprop-1-ene ,Description

2-Chloro-3,3,3-trifluoroprop-1-ene, commonly known as CF3CH2Cl, is a fluorinated hydrocarbon. It is a colorless liquid with a faint, sweet odor. It is a highly reactive compound, and is used in a variety of industrial and laboratory applications. It is a versatile reagent, and has been used in the synthesis of a wide range of compounds, ranging from pharmaceuticals to polymers. It has also been used as a catalyst in organic synthesis. In addition, it has been used as a solvent for a variety of reactions, and has also been used in the production of polymers.
 

Scientific Research Applications

Chemical Synthesis

2-Chloro-3,3,3-trifluoroprop-1-ene, known as HCFO-1233xf, has been utilized in various chemical syntheses. An efficient base-promoted reaction involving O-, N-, and S-nucleophiles with HCFO-1233xf provides access to various β-substituted-trifluoromethyl-ethenes under mild conditions, useful in chemical discovery (Meyer & El Qacemi, 2020). Additionally, HCFO-1233xf is crucial in the palladium-catalyzed double amination synthesis of 1-substituted 2-(trifluoromethyl)indoles, forming two C-N bonds in one pot (Dong et al., 2010).

Physical Properties Research

Studies on the physical properties of HCFO-1233xf have been conducted, focusing on its compressed liquid density and vapor phase PvT measurements (Fedele et al., 2018). Research on vapor pressure measurements and correlation for HCFO-1233zd(E) has also been significant, providing insights into the compound's thermophysical properties (Li et al., 2019).

Medicinal Chemistry

In medicinal chemistry, the chemistry of the 3,3,3-trifluoroprop-1-enyl group, a new fluorine motif, presents attractive characteristics. A novel fluorination reagent was developed for the convenient construction of the trifluoropropenylation group, showing promising applications in drug development (Ikeda, 2019).

Catalytic Processes

The compound plays a role in catalytic processes, like the selective gas-phase catalytic fluorination of 1,1,2,3-tetrachloropropene to 2-chloro-3,3,3-trifluoropropene, a step crucial for the synthesis of 2,3,3,3-tetrafluoropropene (Mao et al., 2014).

Agricultural Chemistry

The compound has been studied for its potential application in agricultural chemistry. For instance, it serves as an important intermediate for tefluthrin, a pesticide used in controlling soil insect pests (Liu et al., 2006).

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