28122-13-6 | 4-FLUOROPHENYLSULFONYLETHANOL

CAS:28122-13-6 | 4-FLUOROPHENYLSULFONYLETHANOL,Description

“2-[(4-Fluorophenyl)sulfonyl]ethanol” is a chemical compound with the CAS Number: 28122-13-6. It has a molecular weight of 204.22 and its linear formula is C8H9FO3S. The compound is typically a colorless to yellow liquid or semi-solid or solid.

Molecular Structure Analysis

The molecular structure of “2-[(4-Fluorophenyl)sulfonyl]ethanol” is represented by the linear formula C8H9FO3S. This indicates that the molecule is composed of 8 carbon atoms, 9 hydrogen atoms, 1 fluorine atom, 3 oxygen atoms, and 1 sulfur atom.

Scientific Research Applications

Application 1: Protection of Hydroxyl Groups in Carbohydrate Chemistry

• Summary of the Application : The 2-[(4-Fluorophenyl)sulfonyl]ethoxy carbonyl (Fsec) group has been designed, synthesized, and evaluated for the protection of hydroxyl groups in carbohydrate chemistry.
• Methods of Application or Experimental Procedures : Fsec-Cl was prepared in 91% yield over three steps and subsequently used to protect 4-fluorobenzyl alcohol. The Fsec group was cleaved from the resulting model compound under mild basic conditions, e.g., 20% piperidine in DMF, and was stable under acidic conditions, e.g., neat acetic acid.
• Results or Outcomes : The Fsec group was used to protect the unreactive 4-OH in a galactose building block that was later used in the synthesis of 6-aminohexyl galabioside.

Application 2: Synthesis of Pyrrole Derivatives

• Summary of the Application : “2-[(4-Fluorophenyl)sulfonyl]ethanol” is used in the synthesis of pyrrole derivatives.
• Methods of Application or Experimental Procedures : An eco-friendly and highly efficient method was developed for the one-pot synthesis of penta-substituted pyrrole derivatives via a four-component reaction.
• Results or Outcomes : The specific outcomes of this application were not detailed in the source.

Safety And Hazards

The safety information for “2-[(4-Fluorophenyl)sulfonyl]ethanol” includes several hazard statements: H301-H311-H331. The precautionary statements include P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501. The compound is labeled with the GHS06 pictogram and the signal word "Danger".

Future Directions

One of the papers retrieved suggests that the Fsec group in “2-[(4-Fluorophenyl)sulfonyl]ethanol” has potential to be used to protect glycosyl donors intended for solid-phase synthesis of glycoconjugates. This indicates a possible future direction for the use of this compound in the field of organic synthesis.

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