2834-23-3 | Chlorodifluoroacetic anhydride

CAS:2834-23-3 | Chlorodifluoroacetic anhydride ,Description

Chlorodifluoroacetic anhydride (CDFA) is a colorless, volatile organic compound used as a reagent in organic synthesis. It is a versatile reagent with a wide range of applications in the chemical industry, including the synthesis of pharmaceuticals, polymers, and other organic compounds. CDFA is also used in laboratory research, where its unique properties make it a useful tool for chemists. In 
 

Scientific Research Applications

1. Photolytic Studies

Chlorodifluoroacetic anhydride has been studied for its photolytic properties. The photolysis of its vapor, particularly using 248 nm radiation, was analyzed, revealing quantum yields of various products like CO, CO2, and CF2Cl2. These findings are significant in understanding the chemical's behavior under light exposure and its potential applications in photochemistry (Watkins & Whittle, 1984) .

2. Mediating Chemical Reactions

Research has developed a practical chlorodifluoromethylation reaction using chlorodifluoroacetic anhydride. This process involves creating diacyl peroxide in situ from the anhydride, demonstrating its utility in mediating allylic and amino-chlorodifluoromethylations of alkenes. This finding is important for synthetic chemistry applications (Kawamura et al., 2018).

3. Synthesis of Fluorinated Compounds

Chlorodifluoroacetic anhydride has been evaluated for its role in synthesizing potential bifunctional fluorinated synthons. This includes reactions with acid chlorides under specific conditions, leading to chlorodifluoromethyl ketones and other fluorinated compounds. Such applications are valuable in the field of fluorine chemistry (Diter, Magnier, & Blazejewski, 2007).

4. Use in Gas Chromatography

The use of chlorodifluoroacetic anhydride in combination with other reactive anhydrides is a method for analyzing protein amino acids via gas chromatography. This application is crucial for biochemical analysis and research (Hušek, 1982) .

5. Synthesis of Isoxazoles

A study has developed an efficient reaction involving vinyl azides and chlorodifluoroacetic anhydride for synthesizing 5-difluoromethyl and 5-chlorodifluoromethyl isoxazoles. This synthesis method is significant for creating these compounds with high yields (Lin, Wu, & Weng, 2020).

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