28781-85-3 | Ethyl 2,2-difluoropropanoate

CAS:28781-85-3 | Ethyl 2,2-difluoropropanoate ,Description

Ethyl 2,2-difluoropropanoate (EDFP) is a fluorinated alkyl ester that has become increasingly popular in recent years due to its unique properties and potential applications in both scientific research and industry. EDFP is a colorless, volatile liquid with a low boiling point and a mild odor. It is chemically stable and highly soluble in both organic and aqueous solvents. As a result, EDFP has become a valuable tool for many researchers in the fields of organic chemistry, materials science, and biochemistry. 
 

Scientific Research Applications

Lithium-Ion Battery Improvement

Ethyl 2,2-difluoropropanoate derivatives, such as ethyl 3,3,3-trifluoropropanoate (TFPE), have been studied for their role in improving the cycling performance of lithium-ion batteries. In research by Huang et al. (2016), TFPE was added to the electrolyte of a LiMn2O4/Li cell, resulting in increased capacity retention and reduced interfacial impedance. This additive inhibits the formation of HF, which erodes the LiMn2O4 electrode, demonstrating its potential in extending battery life and performance at elevated temperatures (Huang et al., 2016).

Chemical Synthesis

Ethyl 2,2-difluoropropanoate and its derivatives are also important in chemical synthesis. Molines and Wakselman (1987) developed a method for synthesizing ethyl 3,3,3-trifluoropropanoate and its 2-bromo derivative. These compounds are produced through the oxidation of acetals formed by the radical addition of halogenated compounds to ethyl vinyl ether, showing the versatility and utility of ethyl 2,2-difluoropropanoate in organic synthesis (Molines & Wakselman, 1987).

Histopathological Studies

In medical research, derivatives of ethyl 2,2-difluoropropanoate, such as ethyl 2-cyanoacrylate, have been investigated for their histopathological effects. A study by Kaplan et al. (2004) explored the use of ethyl 2-cyanoacrylate as a tissue adhesive in cardiovascular and thoracic surgery. The study found no significant histopathological difference between tissues closed with conventional sutures and those with ethyl 2-cyanoacrylate, suggesting its potential as an alternative or adjunct in surgical applications (Kaplan et al., 2004).

Pharmaceutical Research

In pharmaceutical research, Vogt et al. (2013) conducted a study on polymorphic forms of a compound structurally related to ethyl 2,2-difluoropropanoate. They used spectroscopic and diffractometric techniques to characterize the polymorphic forms, providing insights into the challenges of analytical and physical characterization in pharmaceutical compounds (Vogt et al., 2013).

Fluorine Chemistry

In the field of fluorine chemistry, the use of ethyl 2,2-difluoropropanoate derivatives in the synthesis of trifluoromethyl heterocycles was explored by Honey et al. (2012). Their work demonstrates the versatility of ethyl 2-diazo-4,4,4-trifluoro-3-oxobutanoate as an intermediate in synthesizing a diverse set of heterocycles, highlighting its significance in fluorine chemistry (Honey et al., 2012).

More Information