2923-18-4 | Sodium trifluoroacetate

CAS:2923-18-4 | Sodium trifluoroacetate ,Description

Sodium trifluoroacetate (STFA) is a chemical compound often used in research laboratories and in industrial applications. STFA is a colorless, odorless, and non-toxic solid compound that can be used as a reagent in the synthesis of other compounds. It is also used in the production of pharmaceuticals, agrochemicals, and other industrial products. STFA has a wide range of applications in scientific research and laboratory experiments due to its unique properties. 
 

Scientific Research Applications

• Trifluoromethylation: NaTFA, in the presence of copper(I) iodide, is used to replace halogen atoms with trifluoromethyl groups in various compounds. This process is significant in modifying benzenoid and heterocyclic aromatic systems, as well as alkenyl and alkyl halogen compounds. The mechanism involves an intermediate [CF3CuI]− and has been extensively studied (Carr, Chambers, Holmes, & Parker, 1988).
• Chemical Synthesis: NaTFA is employed in the Claisen ester condensation process to produce various compounds like ethyl γγγ-trifluoroacetoacetate and the corresponding ketones. This method highlights the role of sodium in promoting reactions involving perfluoroesters (Burdon & McLoughlin, 1964).
• Study of Hydrogen Bonding: Research on the dissociation pressure and infrared spectra of compounds with sodium trifluoroacetate elucidates the stability of these salt-acid compounds due to strong hydrogen bonding (Klemperer & Pimentel, 1954).
• Environmental Toxicology: NaTFA is studied for its environmental effects, particularly its potential for waterway contamination. Research on its persistence and degradation in water environments is vital, especially in regions where it is used for vertebrate pest control (Booth, Ogilvie, Wright, & Eason, 1999).
• Biochemical Interactions: In biochemical studies, NaTFA has been investigated for its interaction with enzymes like elastase, demonstrating its role as a competitive inhibitor and its interactions observable through NMR spectroscopy (Winninger, Lestienne, Dimicoli, & Bieth, 1978).
• Soil Solution Chemistry: The impact of NaTFA on soil solution chemistry is explored to understand its effects in the presence of increased anion concentrations, a scenario relevant to acid deposition and environmental pollution (Berger & Likens, 1999).
• Modulation of Receptors: NaTFA has been identified as an allosteric modulator at glycine receptors, demonstrating selective actions distinct from other known modulators. This finding is significant for understanding the secondary effects of volatile anesthetics and the variability in peptide-based drug research (Tipps, Iyer, & Mihic, 2012).

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