2926-27-4 | Potassium trifluoromethanesulfonate

CAS:2926-27-4 | Potassium trifluoromethanesulfonate ,Description

Potassium trifluoromethanesulfonate (KTFMS) is an organic compound with the molecular formula KOSO2F3. It is a colorless, odorless, water-soluble salt that is used in a variety of scientific and industrial applications. It is a reagent for the synthesis of organic compounds, and has been used in a variety of biochemical and physiological studies. 
 

Scientific Research Applications

Lewis Acid Catalysis

Potassium trifluoromethanesulfonate, as well as other triflates, have been extensively used as Lewis acid catalysts in chemical reactions. For example, scandium trifluoromethanesulfonate is a highly active Lewis acid catalyst, particularly effective in the acylation of alcohols with acid anhydrides and in the esterification of alcohols by carboxylic acids (Ishihara et al., 1996).

Organic Synthesis

Trifluoromethanesulfonic acid, a related compound, is used in organic synthesis for various reactions such as electrophilic aromatic substitution, formation of carbon-carbon and carbon-heteroatom bonds, and in the synthesis of carboand heterocyclic structures (Kazakova & Vasilyev, 2017).

Post-Polymerization Functionalization

In polymer chemistry, potassium sulfonyl (trifluoromethanesulfonyl)imide derivatives have been synthesized and used in the post-polymerization functionalization of (co)polymers. This involves coupling reactions such as alkylation, amidation, and alkyne–azide cycloaddition (Tintaru et al., 2017).

Catalysis in Acylation Reactions

Trifluoromethanesulfonic acid is noted for its catalytic activity in C- and/or O-acylation, broadening the use of various substrates under different conditions (Tachrim et al., 2017).

Application in Vinyl and Aryl Triflates Synthesis

Vinyl and aryl trifluoromethanesulfonates, which are closely related to potassium trifluorommethanesulfonate, are increasingly used for their facile preparation and diverse applications in organic synthesis. They are particularly notable in cross-coupling reactions and the Heck reaction due to their superior regio- and diastereoselectivity (Ritter, 1993).

Nucleophilic Trapping with Triflic Anhydride

Trifluoromethanesulfonic anhydride, another related compound, is used as an electrophilic activator in synthetic organic chemistry. It facilitates the generation of a triflate intermediate, which undergoes nucleophilic trapping to yield novel compounds. This process is significant in amide, sulfoxide, and phosphorus oxide chemistry (Huang & Kang, 2021).

Synthesis of Stable Multifunctional C-Phosphonio Phosphorus Vinyl Ylides

Potassium trifluoromethanesulfonate-related compounds have been used in the synthesis of unique and stable multifunctional C-phosphonio phosphorus vinyl ylides, highlighting their utility in creating novel phosphorus-containing compounds (Dyer, Baceiredo, & Bertrand, 1996).

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