2926-29-6 | Sodium Trifluoromethanesulfinate

CAS:2926-29-6 | Sodium Trifluoromethanesulfinate ,Description

Sodium Trifluoromethanesulfinate (NaTMS) is a highly reactive, non-toxic, and water-soluble compound that has been used in a variety of scientific research applications. It is a useful reagent for organic synthesis, and its reactivity can be tailored for specific applications. NaTMS is also an important starting material for the synthesis of various fluorinated compounds, such as fluorinated pharmaceuticals and agrochemicals. In addition, it has been used in biochemistry and physiology research to study the mechanism of action of enzymes and other proteins. 
 

Scientific Research Applications

• Trifluoromethylation, Trifluoromethylsulfenylation, and Trifluoromethylsulfinylation: It serves as a versatile reagent in these chemical reactions, useful in various chemical processes (H. Guyon, Hélène Chachignon, & D. Cahard, 2017).
• Selective Oxidation of C–H Bonds: A light and oxygen-enabled photocatalytic system using sodium trifluoromethanesulfinate allows for efficient and environmentally friendly preparation of high-value aromatic ketones and carboxylic acids from readily available materials (Xianjin Zhu, Yong Liu, Can Liu, Haijun Yang, & H. Fu, 2020).
• Pharmaceutical Applications: Recent advancements in trifluoromethylation with sodium trifluoromethanesulfinate have led to improved drug stability, bioavailability, and binding selectivities, benefiting pharmaceutical research (Renjie Hui, Shiwei Zhang, Zheng Tan, Xiaopei Wu, & Bainian Feng, 2017).
• Synthesis of 3-(Trifluoromethyl)-Spiro[4.5]Trienones: Copper-catalyzed difunctionalization of activated alkynes with sodium trifluoromethanesulfinate is employed in synthesizing these compounds, enabling the simultaneous formation of two carbon-carbon single bonds and one carbon-oxygen bond (Huiliang Hua et al., 2015).
• Oxidative Trifluoromethylation and Arylation: The copper-catalyzed process shows potential for the facile generation of CF3 radicals under mild conditions (Qingquan Lu et al., 2014) .

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