307-24-4 | Perfluorohexanoic acid

CAS:307-24-4 | Perfluorohexanoic acid ,Description

Perfluorohexanoic acid (PFHxA) is a synthetic fluorinated organic acid that is used in a variety of applications. It is a colorless, odorless, and non-toxic compound that is chemically stable and has a low vapor pressure. PFHxA is used in a variety of industries, including pharmaceuticals, electronics, and oil and gas production. The compound has also been studied for its potential use in medical applications, such as drug delivery and tissue engineering.
 

Scientific Research Applications

Molecular Interactions

• PFHxA, along with other perfluorinated carboxylic acids, has been studied for its interactions with human sera and human serum albumin. These interactions are significant for understanding the bioaccumulation of such molecules in human blood. Nuclear magnetic resonance spectroscopy has identified human serum albumin as a major interaction site for PFHxA, highlighting its potential impact on the pharmacokinetics and distribution of fatty acids and certain drugs in the human body (D’eon et al., 2010) .

Environmental Distribution

• PFHxA has been identified as a significant contaminant in various environmental settings, including river and seawater samples in Japan. The high levels of PFHxA detected in these studies indicate its widespread distribution in the aquatic environment and potential human exposure (Takemine et al., 2014).

Treatment and Degradation

• An effective strategy for the removal and degradation of PFHxA from industrial process waters has been developed, involving nanofiltration and electrochemical degradation. This method has shown significant potential in treating PFHxA-contaminated waters, highlighting its persistence as a pollutant and the need for efficient treatment technologies (Soriano et al., 2017).

Toxicity and Health Risks

• Comprehensive reviews and toxicity studies have been conducted to assess the potential human health risks associated with PFHxA. These studies have concluded that PFHxA is not carcinogenic, does not disrupt endocrine activity, and its effects are largely limited to potential kidney effects, which occur at much higher doses than those observed for other related compounds (Luz et al., 2019).

Biomonitoring and Exposure Assessment

• Analytical methods have been developed for biomonitoring PFHxA in human urine, providing a means to assess exposure. Such methods are crucial for understanding the extent of human exposure to PFHxA and related compounds (Jurado‐Sánchez et al., 2014) .

Mechanisms of Toxicity

• Multi-omics approaches have been applied to study the toxicity mechanism of PFHxA in mice, particularly focusing on its impact on liver function. This comprehensive approach has provided new insights into the biological processes affected by PFHxA exposure, including fatty acid biosynthesis and degradation pathways influenced by the peroxisome proliferator-activated receptor signaling pathway (Jiang et al., 2021).

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