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2-Bromo-3,3,3-trifluoropropan-1-ol (2-Br-TFP) is a versatile organic compound with a wide range of applications in scientific research and industry. It is a colorless liquid with a pleasant odor and a boiling point of 99.2 °C. 2-Br-TFP is a member of the halogenated aliphatic alcohols, and is a halogenated derivative o...
2-Bromo-3,3,3-trifluoropropan-1-ol (2-Br-TFP) is a versatile organic compound with a wide range of applications in scientific research and industry. It is a colorless liquid with a pleasant odor and a boiling point of 99.2 °C. 2-Br-TFP is a member of the halogenated aliphatic alcohols, and is a halogenated derivative of propan-1-ol. It is used in a variety of synthetic reactions, and is a useful reagent for organic synthesis.
2-Bromo-3,3,3-trifluoropropan-1-ol is used as a starting material in the synthesis of various organic compounds. Inoue, Shiosaki, and Muramaru (2014) utilized it in synthesizing ethyl 3,3,3-trifluoropropionate, a compound achieved through a tandem reaction mechanism (Inoue, Shiosaki, & Muramaru, 2014). Zeng et al. (2022) employed it in a photocatalytic defluorinative reaction with N-aryl amino acids, leading to the synthesis of 4-(difluoromethylidene)-tetrahydroquinolines (Zeng, Li, Chen, & Zhou, 2022).
Ye et al. (2015) studied the chemical shift sensitivity of trifluoromethyl tags in 19F NMR, including 2-bromo-3,3,3-trifluoropropan-1-ol. This study highlights its application in analyzing protein structures and conformations (Ye, Larda, Li, Manglik, & Prosser, 2015).
Yamauchi, Hara, and Senboku (2010) explored the electrochemical carboxylation of related compounds to synthesize 2-aryl-3,3,3-trifluoropropanoic acids, further applied in creating β,β,β-trifluorinated non-steroidal anti-inflammatory drugs (Yamauchi, Hara, & Senboku, 2010).
Lou et al. (2019) developed a palladium-catalyzed cross-coupling method using 2-Bromo-3,3,3-trifluoropropene for the synthesis of trifluoromethylated and difluoromethylated amino acids. These amino acids have applications in medicinal chemistry and life science (Lou, Wang, Zhao, He, Li, He, & Zhang, 2019).
Chen, Zhou, and Han (2015) conducted theoretical and experimental studies on the atmospheric degradation of 2-Bromo-3,3,3-trifluoropropene, examining its use as a fire extinguishing agent (Chen, Zhou, & Han, 2015).
Product Name : | 2-Bromo-3,3,3-trifluoropropan-1-ol | ||
CAS No. : | 311-86-4 | Molecular Weight : | 192.96 |
MDL No. : | MFCD09763638 | Purity/ Specification : | |
Molecular Formula : | C3H4BrF3O | Storage : | Sealed in dry,2-8°C |
Boiling Point : | - |
GHS Pictogram : | |||
Signal Word : | Danger | Precautionary Statements : | P210-P261-P305+P351+P338 |
UN# : | 1993 | Class : | 3 |
Hazard Statements : | H225-H315-H319-H335 | Packing Group : | Ⅲ |