311-89-7 | Heptacosafluorotributylamine

CAS:311-89-7 | Heptacosafluorotributylamine ,Description

Heptacosafluorotributylamine (HFTBA) is a fluorinated organic compound that is used as a reagent in organic synthesis and as a modifier in chromatographic separations. It is a colorless liquid with a low vapor pressure and a low boiling point. It is soluble in organic solvents, such as ether and benzene, and is insoluble in water. HFTBA is a versatile compound and has a wide range of applications in scientific research. 
 

Scientific Research Applications

• Photocaging Groups Activated by Near-IR Light: A study explored the use of heptamethine cyanines, including derivatives of heptacosafluorotributylamine, for near-IR light-initiated uncaging reactions. This technology is significant for controlled drug delivery and gene expression manipulation using near-IR light, which is biologically compatible and tissue-penetrant (Gorka et al., 2014).
• Culture Surface for Anchorage-Independent Cell Growth: Research demonstrated the use of heptacosafluorotributylamine as a culture surface for various cell lines under anchorage-independent conditions. This method, contrasting with traditional soft agar culture, offers ease of cell plating, ability to recover cells and secreted products, and requires a shorter growth period (Sanfilippo et al., 2007).
• Optical Imaging and Drug Delivery: Heptamethine cyanines, including derivatives of heptacosafluorotributylamine, were investigated for their potential in optical imaging and drug delivery. The study highlights the unique chemical reactivity of these compounds, which could be harnessed for creating novel probe molecules useful in complex imaging and therapeutic settings (Gorka et al., 2018).
• Enhancing Reporter Gene Expression in Pulmonary Therapeutics: A study used heptacosafluorotributylamine to deliver plasmid DNA to the lungs of mice. This approach, leveraging the unique properties of perfluorocarbons like heptacosafluorotributylamine, demonstrated enhanced gene expression, indicating potential applications in pulmonary gene therapy (Das & Niven, 2001).
• Experimental Vitreous Replacement in Ophthalmology: In ophthalmology, heptacosafluorotributylamine was evaluated as a vitreous substitute in rabbit eyes. Although it showed some potential for retinal tamponade, its use led to the formation of cell clusters and other histopathologic changes (Chang et al., 1987).

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