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2,2,2-Trifluoroethyl formate (TFF) is an important organic compound that has a wide range of applications in the scientific and industrial fields. It is a colorless liquid with a pungent odor and is soluble in most organic solvents. TFF is a versatile compound that has been used in a variety of synthetic reactions, as ...
2,2,2-Trifluoroethyl formate (TFF) is an important organic compound that has a wide range of applications in the scientific and industrial fields. It is a colorless liquid with a pungent odor and is soluble in most organic solvents. TFF is a versatile compound that has been used in a variety of synthetic reactions, as well as in the production of pharmaceuticals, biochemicals, and other products. It is also used in the production of polymers, catalysts, and other materials.
2,2,2-Trifluoroethyl formate is employed in organic synthesis, particularly in the direct formylation of kinetically-generated ketone enolates. This process yields α-formyl ketones efficiently, reversing the regioselectivity of the classical Claisen reaction and providing an improved method for α‘-formylation of α,β-unsaturated ketones (Zayia, 1999).
In atmospheric chemistry, 2,2,2-trifluoroethyl formate is a notable degradation product of fluroxene oxidation. Studies show it forms primarily through reactions with OH and Cl radicals and is a significant contributor to climate change due to its radiative efficiencies (Bravo et al., 2013).
The molecule has been the subject of detailed spectroscopic studies. For example, its rotational spectra and molecular structure have been analyzed using chirped pulse Fourier transform microwave spectrometry, enhancing our understanding of molecular behavior and stability (Evangelisti et al., 2011).
2,2,2-Trifluoroethyl formate has been characterized for its physical properties, such as melting and boiling points, solubility, and its methods of preparation and purification. This information is crucial for its handling and application in various chemical processes (Smith, 2010) .
In mass spectrometry, particularly in negative-ion electrospray ionization, 2,2,2-trifluoroethyl formate enhances the response of analytes, making it valuable in pharmacokinetic and drug metabolism studies (Wu et al., 2004).
The compound plays a role in the fluorination of organic molecules, a technique widely used in drug design for its ability to modify biological activities. Its use in palladium-catalyzed 2,2,2-trifluoroethylation of organoboronic acids and esters highlights its significance in medicinal chemistry and related fields (Zhao & Hu, 2012).
Product Name : | 2,2,2-Trifluoroethyl formate | ||
CAS No. : | 32042-38-9 | Molecular Weight : | 128.05 |
MDL No. : | MFCD06797733 | Purity/ Specification : | |
Molecular Formula : | C3H3F3O2 | Storage : | Sealed in dry,Room Temperature |
Boiling Point : | - |
GHS Pictogram : | |||
Signal Word : | Danger | Precautionary Statements : | P210-P280-P301+P312+P330-P305+P351+P338-P370+P378-P403+P235 |
UN# : | 1993 | Class : | 3 |
Hazard Statements : | H225-H302-H319-H335-H351 | Packing Group : | Ⅱ |