33420-52-9 | 2,2-Difluoropropanol

CAS:33420-52-9 | 2,2-Difluoropropanol ,Description

2,2-Difluoropropanol is an organic compound that is part of the family of difluorinated alcohols. It is a colorless liquid with a sweetish odor and a boiling point of 108.2 °C. It is used in a variety of industrial and research applications, including as a solvent, a fuel additive, and a reagent in chemical synthesis. It has been studied for its biochemical and physiological effects, and has been shown to have potential applications in laboratory experiments. 
 

Scientific Research Applications

Peptide Structure Stabilization

2,2-Difluoropropanol and related fluoroalcohols, like hexafluoroacetone trihydrate, play a significant role in stabilizing secondary structures in peptides in aqueous solutions. The molecular mechanisms behind this stabilization are not entirely clear, but these fluoroalcohols, particularly 2,2,2-trifluoroethanol (TFE), are widely used additives in aqueous solutions of peptides and proteins to induce intramolecularly hydrogen-bonded conformations (Rajan, Awasthi, Bhattacharjya, & Balaram, 1997).

Synthesis of Fluorinated Telomers

1,1-Difluoro-2-chloroethylene and 1,2-difluoro-1,2-dichloroethylene can be radical telomerized with methanol to produce chlorofluoroalcohols such as 3-chloro-2,2-difluoropropanol. This process demonstrates the influence of fluorine and chlorine atoms in directing radical reactions and the high conversion rates of these telomerizations (Guiot, Améduri, Boutevin, & Fruchier, 2002).

Properties of Fluoroalcohol Mixtures

Mixtures of fluoroalcohols, such as 2,2,2-trifluoroethanol (TFE) with water, have been studied for their effects on the solubility and stability of peptides. Molecular dynamics simulations of these mixtures help improve the understanding of their properties, such as densities, diffusion constants, and dielectric constants (Chitra & Smith, 2001).

Fluorination in Organic Synthesis

2,2-Difluoropropanol is involved in various fluorination reactions in organic synthesis, such as the selective difluoromethylation and monofluoromethylation reactions. These methods are crucial in introducing fluorinated moieties into organic molecules, which have significant implications in pharmaceutical and agrochemical development (Hu, Zhang, & Wang, 2009).

Use in Electrocatalytic Reactions

An electrocatalytic reactor with nano-MnOx loading porous Ti electrode as an anode has been used for the oxidation of 2,2,3,3-tetrafluoro-1-propanol to producehigh-value chemicals like sodium 2,2,3,3-tetrafluoropropionate. This study highlights the role of 2,2-Difluoropropanol derivatives in green chemistry and their potential in producing chemicals through environmentally friendly processes (Wang, Wang, Li, Bin, Yin, Kang, & He, 2014).

Photodegradation Studies

The photodegradation of perfluorooctane sulfonate in water and alkaline 2-propanol solutions, where compounds related to 2,2-Difluoropropanol play a role, was investigated. This research contributes to understanding the environmental impact and degradation pathways of persistent organic pollutants (Yamamoto, Noma, Sakai, & Shibata, 2007).

Fluoroalcohols in Hypervalent Iodine Chemistry

Fluoroalcohols like 1,1,1,3,3,3-hexafluoroisopropanol and 2,2,2-trifluoroethanol have been used as solvents in hypervalent iodine-mediated phenolic oxidations. They stabilize reactive cationic intermediates and facilitate various transformations in organic synthesis, demonstrating the versatility of fluoroalcohols in chemical reactions (Dohi, Yamaoka, & Kita, 2010).

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