336-59-4 | Heptafluorobutyric anhydride

CAS:336-59-4 | Heptafluorobutyric anhydride ,Description

Heptafluorobutyric anhydride (HFBA) is a chemical compound that is used in a wide range of applications, from industrial synthesis to scientific research. It is an anhydride, which means that it is a compound formed when two molecules of a carboxylic acid are combined with the removal of water. HFBA is a colorless, volatile liquid with a strong odor, and it is highly reactive, making it a useful tool for many applications.
 

Scientific Research Applications

1. Analytical Applications in Chromatography

• Gas Chromatography of Amino Acids: HFBA is used in the derivatization of amino acids for their analysis through gas chromatography, offering a sensitive and quick method. This process is particularly efficient because it preserves the integrity of sensitive amino acids like glutamine and asparagine during the chemical treatment (Hušek, 1982) .
• Determination of Herbicides: HFBA has been applied to the derivatization of phenylurea herbicides, allowing their efficient detection and quantification in water and crop samples via chromatographic methods (Brinkman, Kok, & Geerdink, 1984).
• Analysis of Catecholamines: In the field of biochemistry, HFBA is utilized to form derivatives of catecholamines, enhancing their detection sensitivity in gas-liquid chromatographic analysis (Sakauchi, Kumaoka, & Hanawa, 1972).

2. Synthetic Applications

• Steroid Chemistry: HFBA is employed in the preparation of steroid olefins from heptafluorobutyrates, demonstrating its utility in organic synthesis and steroid chemistry (Dalibová & Kohout, 1998) .
• Steroid Sulfates: The compound is also effective in the acylation of steroid sulfates, allowing for their quantitative analysis in biological samples (Touchstone & Dobbins, 1975).
• Perfluoroacylation Studies: Research into the perfluoroacylation of certain compounds, like tocainide, uses HFBA, highlighting its role in understanding the stability and degradation of perfluoroacyl derivatives (Gyllenhaal et al., 1986).

More Information