338-76-1 | Methyl 2-fluoro-2-methylpropanoate

CAS:338-76-1 | Methyl 2-fluoro-2-methylpropanoate ,Description

Methyl 2-fluoro-2-methylpropanoate (MFMP) is a versatile organic compound with a wide range of applications in the fields of organic synthesis, medicinal chemistry, and biochemistry. It is a colorless liquid with a boiling point of 61°C and a melting point of -20°C. MFMP is used as a solvent, a reagent, and a catalyst in various laboratory experiments. It is used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used in the production of coatings, adhesives, and other polymers.
 

Scientific Research Applications

• Synthesis of Optically Active Compounds:
  • Methyl 2-fluoro-2-methylpropanoate is used in the synthesis of optically active compounds, such as 2-fluoropropanoic acid and its analogs. These compounds are synthesized with high enantiomeric purity, which is crucial in pharmaceuticals and biologically active substances (Fritz-Langhals & Schütz, 1993).
• Modification of Pharmaceutical Compounds:
  • It is used in modifying the side chain of pharmaceutical compounds like taxol, a well-known anticancer drug. For instance, the synthesis of fluorine analogs of the C-13 side chain of taxol has been reported using this compound (Davis & Reddy, 1994).
• Chemical Synthesis and Storage:
  • The compound is utilized in chemical synthesis methods. A novel and facile method for its synthesis has been developed, which is important for extending its storage life and reducing costs associated with shipment and storage (Fu et al., 2022).
• Development of Polyurethane Materials:
  • In material science, it is used in the synthesis of fluorinated polyurethane materials. These materials have enhanced properties like high elongation at break and improved water-resistance, which are important in various industrial applications (Yu et al., 2018).
• Radiolabeling for Tumor Imaging:
  • It also finds application in the field of medicinal chemistry, specifically in the synthesis of radiolabeled amino acids for tumor imaging in positron emission tomography (PET) (Yu et al., 2010; McConathy et al., 2002).
• Fluorination Reactions:
  • The compound is involved in fluorination reactions, like the fluorination of 2-methylpropane over cobalt trifluoride, demonstrating its utility in complex chemical processes (Burdon et al., 1977).
• Conformational Analysis:
  • Studies involving conformational behavior through NMR and IR spectroscopy have been conducted on methyl 2-fluoroesters, including methyl 2-fluoropropionate, providing insights into the molecular structure and behavior of these compounds (Tormena et al., 2004).
• Catalysis:
  • In catalysis, it is used in reactions like the hydroesterification of propene into methyl 2-methylpropanoate, highlighting its role in industrial chemical processes (Bertoux et al., 1998).
• Antitumor Activity:
  • Research has been conducted on the synthesis of compounds with antitumor activities, where derivatives of methyl 2-fluoro-2-methylpropanoate were synthesized and tested for their efficacy against tumors (Wang Yuan-chao, 2011).
• Electrochemistry:
  • The compound has applications in electrochemistry, for instance, as an SEI-forming additive in lithium-ion batteries, which is crucial for enhancing battery performance (Krämer et al., 2012) .
• Biocatalytic Synthesis:
  • It is used in biocatalytic synthesis processes, such as the production of 2-fluoro-3-hydroxypropionic acid, an important compound in developing new biosynthetic strategies that integrate synthetic and natural compounds (Liu et al., 2022).

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