338-83-0 | Tris(perfluoropropyl)amine

CAS:338-83-0 | Tris(perfluoropropyl)amine ,Description

Tris(perfluoropropyl)amine (TFP) is a perfluorinated amine that has a broad range of applications in research, industry, and medicine. It is a highly hydrophobic and lipophilic molecule that is used in many scientific and industrial processes. TFP is used as a surfactant, emulsifier, and catalyst in various processes, as well as a corrosion inhibitor and a dispersant. In addition, it has been used extensively in research studies due to its ability to selectively interact with various biological molecules.
 

Scientific Research Applications

Synthesis and Functionalization

Tris(hydroxymethyl)aminomethane (TRIS) forms the basis for synthesizing three-fold polyfluoroalkylated amines and isocyanates. These compounds are prepared in a multi-step process that includes perfluoroalkyl iodide addition to the corresponding allyl derivative, C–I bond reduction, and deprotection of the amino group. The synthesized amines can then be converted into corresponding isocyanates, showcasing the versatility of TRIS in chemical synthesis (Kaplánek et al., 2007) .

Drug Delivery and Hydrogel Applications

A study explored the utilization of tris(2-(2-formylphenoxy)ethyl)amine in designing and synthesizing new pH- and thermo-responsive chitosan hydrogels. These hydrogels were cross-linked through the formation of covalent Schiff-base linkage. The study evaluated the structure and properties of the hydrogels, investigating their swelling behavior at different pHs and temperatures. Moreover, the in vitro controlled release behavior of the metronidazole model drug was studied with these hydrogels. The results highlighted the hydrogels' pH and temperature-responsive swelling ratio and their significant impact on the drug release behavior of the swollen polymers. These findings suggest potential applications of these smart hydrogels in targeted drug delivery and other research fields (Karimi et al., 2018).

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