34202-69-2 | Hexafluoroacetone trihydrate

CAS:34202-69-2 | Hexafluoroacetone trihydrate ,Description

Hexafluoroacetone trihydrate (HFA) is an organofluorine compound that has a wide range of applications. It is a colorless, odorless, and nonflammable solid that is used in a variety of fields including biochemistry, organic synthesis, and analytical chemistry. HFA is also used as a reagent in the synthesis of a variety of compounds, and has been studied for its potential applications in environmental remediation and drug development. HFA is a promising chemical with many potential uses and applications, and 
 

Scientific Research Applications

• Synthesis of Hexafluoroisopropanol Functionalized Derivatives: HFA is effective in the carbonyl-ene reaction with alkenes to produce hexafluoroisopropanol functionalized derivatives. This reaction can be facilitated using molecular sieves and microwave or conventional heating, resulting in high yields (Sridhar et al., 2009).
• Preparation of Fluorinated Compounds: The amidinate salt of HFA is a powerful reagent for preparing fluorinated organic molecules. It enables nucleophilic trifluoromethylation reactions, producing fluoroform and trifluoromethylated products in excellent yields (Riofski et al., 2013).
• Stabilization of Peptide Structures: HFA has been documented to stabilize secondary structures in peptides in aqueous solutions. Its ability to induce intramolecularly hydrogen-bonded conformations in peptides is significant for peptide conformational analysis (Rajan et al., 1997).
• Synthesis of Semi-Fluorinated Polyaryl Ethers: HFA is used in the electrophilic polymerization of diphenyl ether to create semi-fluorinated polyaryl ethers with high regioselectivity and molecular weight. These polymers exhibit unique properties like high solubility, thermal stability, and optical clarity (Muñoz et al., 2022) .
• Manufacturing of SiO2-based Aerogels: HFA hydrate significantly influences the physicochemical parameters of SiO2 aerogels. It enhances specific surface areas and leads to the incorporation of chemically bound fluorine in the aerogels (Lermontov et al., 2015).

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