34451-25-7 | 2-(Perfluorobutyl)ethanethiol

CAS:34451-25-7 | 2-(Perfluorobutyl)ethanethiol ,Description

2-(Perfluorobutyl)ethanethiol (2-PFBT) is an organosulfur compound that has been used in a wide range of applications due to its unique properties. It is a colorless, volatile liquid with a faint, sweet odor and a boiling point of 160°C. 2-PFBT is a perfluorinated alkylthiol, a group of compounds that have been extensively studied for their potential applications in a variety of fields, including drug delivery, biochemistry, and nanotechnology. This article will discuss the synthesis method, scientific research applications, mechanism of action, biochemical and physiological effects, advantages and limitations for lab experiments, and future directions of 2-PFBT. 
 

Scientific Research Applications

Application in Immunoarrays

"Oriented immobilization of antibodies by a self-assembled monolayer of 2-(biotinamido)ethanethiol for immunoarray preparation" (2006) by Jung et al., explores the use of a compound structurally similar to 2-(Perfluorobutyl)ethanethiol in immobilizing antibodies on gold surfaces for immunoarrays. This study demonstrates the potential of related thiol compounds in enhancing antibody-antigen interactions in immunoarray technology (Jung et al., 2006).

Development of Odorless Deprotection Agents

Magano et al. (2006) describe "2-(Diethylamino)ethanethiol, a new reagent for the odorless deprotection of aromatic methyl ethers." This research indicates the utility of ethanethiol derivatives in creating odorless reagents for the deprotection of aromatic methyl ethers, a significant advancement in chemical synthesis (Magano et al., 2006).

Magnetic Properties in Metal Thiolate Cages

The study "Single-Molecule Magnetism in Tetrametallic Terbium and Dysprosium Thiolate Cages" (2013) by Woodruff et al., examines the magnetic susceptibility of thiolate-bridged tetralanthanide compounds, highlighting the significance of ethanethiol derivatives in studying magnetic properties of metal compounds (Woodruff et al., 2013).

Interaction with Ionic Liquids

Martínez-Magadán et al. (2012) conducted a "DFT study of the interaction between ethanethiol and Fe-containing ionic liquids for desulfuration of natural gasoline." This research offers insights into the interactions of ethanethiol with ionic liquids, important for applications in desulfurization processes (Martínez-Magadán et al., 2012) .

Synthesis and Characterization of Disulfide Polymers

Rosenthal et al. (2012) discuss the "Green polymer chemistry: living dithiol polymerization via cyclic intermediates," showing the role of ethanethiol derivatives in synthesizing and characterizing disulfide polymers, a key area in green chemistry (Rosenthal et al., 2012).

Design of Fluorescent Probes for Mercury Detection

Cheng et al. (2010) in their study, "A new approach to design ratiometric fluorescent probe for mercury(II) based on the Hg(2+)-promoted deprotection of thioacetals," describe the development of fluorescent chemosensors using ethanethiol derivatives. These sensors are significant for detecting mercury ions, highlighting the application of such compounds in environmental monitoring and public health (Cheng et al., 2010).

Conformational Analysis in Low Temperature Spectroscopy

Smith et al. (1968) conducted a "Conformational analysis of ethanethiol and 2-propanethiol," where they explored different molecular conformations of ethanethiol. This study is crucial for understanding the physical properties of these compounds, which can be applied in various chemical processes and material science (Smith et al., 1968).

Thermal Decomposition Mechanism

Vasiliou et al. (2017) studied the "Thermal Decomposition Mechanism for Ethanethiol," providing valuable insights into its decomposition pathways. This research is significant for industries dealing with ethanethiol and its derivatives, particularly in safety and environmental contexts (Vasiliou et al., 2017).

Synthesis and Structural Characterization in Zinc(II) Complexes

Mikuriya et al. (1998) in their paper on "Synthesis and Structural Characterization of Thiolato-Bridged Zinc (II) Complexes with NNS-Tridentate Thiolic Ligands," highlight the importance of ethanethiol derivatives in the synthesis and structural analysis of zinc complexes, which is relevant in coordination chemistry and material sciences (Mikuriya et al., 1998).

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