34451-26-8 | 2-(Perfluorohexyl)ethanethiol

CAS:34451-26-8 | 2-(Perfluorohexyl)ethanethiol ,Description

2-(Perfluorohexyl)ethanethiol, also known as 6FET, is a perfluorinated alkylthiol compound that has a wide range of uses in scientific research. It is a colorless, odorless liquid that has a low vapor pressure and a boiling point of 149 °C. 6FET is used in a variety of applications, including biochemical and physiological research, as well as in laboratory experiments. 
 

Scientific Research Applications

Environmental Remediation

One notable application of compounds related to 2-(Perfluorohexyl)ethanethiol is in environmental remediation, particularly in the electrochemical mineralization of perfluorinated carboxylic acids (PFCAs). A study demonstrated the use of Ce-doped modified porous nanocrystalline PbO2 film electrodes for the degradation of PFCAs, including perfluorohexanoic acid (PFHxA), in aqueous solutions. This process follows pseudo-first-order kinetics, and the degradation pathway suggests a combination of Kolbe decarboxylation and reaction with hydroxyl radicals, leading to mineralization products such as fluoride ions and shorter-chain PFCAs (Niu, Lin, Xu, Wu, & Li, 2012).

Enhancement of Enzymatic Reactions

In the realm of biochemistry, perfluorinated alkanoic acids, similar in structure to 2-(Perfluorohexyl)ethanethiol, have been shown to elicit certain enzymes like P450BM3 to catalyze the hydroxylation of small alkanes, such as methane. This indicates a potential application of perfluorinated compounds in biotechnological processes that require specific enzyme-catalyzed reactions. Molecular dynamics and quantum mechanical/molecular mechanical (QM/MM) calculations have been used to understand the mechanism behind this activation, which relies on the presence of the perfluorinated compound to induce a productive enzyme-substrate alignment (Li & Shaik, 2013).

Free-Radical Chemistry

The free-radical addition of 2-(perfluoroalkyl)ethanethiols, which include compounds like 2-(Perfluorohexyl)ethanethiol, to various unsaturated compounds has been extensively studied. These reactions are crucial in understanding the reactivity and potential applications of these compounds in creating new materials or in synthetic organic chemistry. The study has shown high yields of adducts from reactions with alkenes, indicating the efficiency and utility of these reactions in synthesizing new perfluorinated compounds with various applications (Brace, 1993).

Polymer Chemistry

In polymer science, 2-(Perfluorohexyl)ethanethiol related compounds play a significant role in the synthesis and modification of polymers. For instance, the synthesis and characterization of disulfide polymers from derivatives of ethanethiols have been reported, with potential applications in creating environmentally friendly polymers. These polymers exhibit unique thermal properties and degradability, making them suitable for various industrial applications (Rosenthal, Puskas, & Wesdemiotis, 2012).

Analytical Chemistry

In analytical chemistry, perfluorinated compounds, akin to 2-(Perfluorohexyl)ethanethiol, have been utilized in the development of novel analytical methods. For example, perfluorinated alkanoic acids have been used to probe the relationship between halogen bonding, hydrogen bonding, desolvation, and the electrostatics of non-covalent interactions, providing insights into the complex nature of these interactions and their potential applications in analytical methodologies (Cabot & Hunter, 2009).

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