346-34-9 | 4-Fluoroindoline-2,3-dione

CAS:346-34-9 | 4-Fluoroindoline-2,3-dione,Description

4-Fluoroindoline-2,3-dione, also known as 4-fluoro-1H-indole-2,3-dione, is a chemical compound with the molecular formula C8H4FNO2 and a molecular weight of 165.12. It is a solid substance at room temperature.

Molecular Structure Analysis

The InChI code for 4-Fluoroindoline-2,3-dione is 1S/C8H4FNO2/c9-4-2-1-3-5-6(4)7(11)8(12)10-5/h1-3H,(H,10,11,12). This code provides a detailed description of the molecule’s structure.

Chemical Reactions Analysis

While specific chemical reactions involving 4-Fluoroindoline-2,3-dione are not available, fluorinated indoles in general have been noted for their reactivity, selectivity, and biological activity.

Physical And Chemical Properties Analysis

4-Fluoroindoline-2,3-dione has a density of 1.477. It is stored at room temperature and is a solid substance.

Scientific Research Applications

1. Synthesis of Novel Fluorinated Indole Derivatives

• Application Summary : 4-Fluoroindoline-2,3-dione is used in the synthesis of novel fluorinated indole derivatives. These fluorinated indoles have received considerable attention because the incorporation of fluorine into a target molecule can influence reactivity, selectivity, and biological activity.
• Methods of Application : The synthesis of these novel fluorinated indole derivatives is developed by the reaction of 5-fluoroindoline-2,3-dione with various anilines. This reaction is conducted using readily available substrates within short periods of 9–15 minutes under microwave irradiation.
• Results or Outcomes : The reaction yields good to excellent yields of the product (64–92%). This approach exploits the synthetic potential of microwave irradiation and copper dipyridine dichloride (CuPy 2 Cl 2) combination and offers many advantages such as full reaction control, excellent product yields, shorter reaction time, eco-friendly procedure, and rapid feedback.

2. Analytical Applications of Fluorine Substituted Spirosteroidalthiazolidin-4-One Derivatives

• Application Summary : 4-Fluoroindoline-2,3-dione might be used in the synthesis of some fluorine substituted spirosteroidalthiazolidin-4-one derivatives of sulfa drugs.
• Methods of Application : The specific methods of application or experimental procedures are not detailed in the source.
• Results or Outcomes : The specific results or outcomes obtained are not detailed in the source.

Safety And Hazards

The compound is labeled with the signal word “Warning” and has hazard statements H302 and H317. This indicates that it is harmful if swallowed and may cause an allergic skin reaction. Precautionary measures include avoiding dust formation, avoiding breathing in mist, gas, or vapors, and avoiding contact with skin and eyes.

Future Directions

Fluorinated indoles, such as 4-Fluoroindoline-2,3-dione, have received considerable attention due to the influence of fluorine on reactivity, selectivity, and biological activity. Future research may focus on the development of novel fluorinated indole derivatives and their potential applications.

More Information