349-43-9 | Ethyl 2-Fluoropropionate

CAS:349-43-9 | Ethyl 2-Fluoropropionate ,Description

Ethyl 2-Fluoropropionate (EFP) is a synthetic organic compound with a wide range of applications in both scientific research and industrial production. It is a colorless, volatile liquid with a characteristic sweet odor. EFP is a derivative of propionic acid and is used as a flavoring agent, a preservative, and an intermediate in the synthesis of other compounds. It is also used as a reagent in the synthesis of pharmaceuticals and other organic compounds.
 

Scientific Research Applications

• Solvent for Lithium Secondary Batteries: Ethyl 2-fluoropropionate (E2FP) has been used as an organic solvent in lithium secondary batteries. Studies show that E2FP offers advantages such as higher ionic conductivities and improved discharge capacities, making it a promising component in battery technology (Nambu et al., 2012).
• Synthesis of Optically Active Compounds: E2FP has been utilized in the synthesis of optically active 2-aryl-2-fluoropropionic acids, which are important analogues of non-steroidal anti-inflammatory drugs (NSAIDs) (Fujisawa et al., 2005).
• Radiolabeling in PET Imaging: The compound has been used in the radiolabeling of proteins and peptides for targeted imaging using positron emission tomography (PET), a significant tool in medical diagnostics (Mařı́k et al., 2006) .
• Conformational Analysis of Methyl 2-Fluoroesters: E2FP has been studied for its conformational behavior using a combination of NMR, theoretical calculations, and spectroscopy. Such studies provide insights into the molecular structure and behavior of fluorinated compounds (Tormena et al., 2004).
• Imaging Hypoxic Tissue in Tumors: E2FP derivatives have been explored for imaging hypoxic tissue in tumors. This application is significant for monitoring tumor progression and response to treatment in cancer research (Zhang et al., 2019).
• Biocatalytic Synthesis: E2FP has been synthesized biocatalytically, highlighting its potential in eco-friendly and sustainable chemical processes (Liu et al., 2022).
• Automated Radiosynthesis: Automated synthesis of 2-18F-Fluoropropionic acid, a derivative of E2FP, has shown potential for PET imaging, particularly in prostate cancer detection (Hongliang et al., 2012).

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