352-23-8 | Ethyl 3,3,3-trifluoropropanoate

CAS:352-23-8 | Ethyl 3,3,3-trifluoropropanoate ,Description

Ethyl 3,3,3-trifluoropropanoate (ETFP) is a synthetic organic compound with the molecular formula C4H7F3O2. It is a colorless liquid with a sweet, fruity odor, and is used in a variety of applications ranging from industrial solvents to flavoring agents. ETFP is a key intermediate in the synthesis of a number of important molecules, including pharmaceuticals, fragrances, and food additives. It is also used in a variety of laboratory experiments, due to its low toxicity and wide range of applications. 
 

Scientific Research Applications

Lithium-Ion Battery Improvement

Ethyl 3,3,3-trifluoropropanoate (TFPE) is notably used as an additive in lithium-ion batteries to enhance their performance, especially at elevated temperatures. In a study, TFPE was added to the electrolyte of LiMn2O4/Li cells, resulting in a 13.2% increase in capacity retention after 200 charge/discharge cycles at 55°C. This improvement is attributed to the additive's ability to inhibit HF-induced erosion of the LiMn2O4 electrode and reduce interfacial impedance (Huang et al., 2016).

Enhancing High-Voltage Cycling Performance

TFPE, along with methyl 3,3,3-trifluoropropanoate (TFPM), significantly enhances the high-voltage performance of LiNi1/3Co1/3Mn1/3O2/graphite lithium-ion batteries. The addition of these additives to the electrolyte increases capacity retention from 45.6% to over 75% after 100 charge-discharge cycles. The improved cycling activity is linked to the formation of a thinner cathode/electrolyte interfacial film, reducing interfacial resistance at high voltage (Zheng et al., 2017).

Chemical Synthesis and Derivatives

Ethyl 3,3,3-trifluoropropanoate and its derivatives are synthesized for various applications. For instance, it has been used in the synthesis of ethyl 2-bromo-3,3,3-trifluoropropanoate, serving as intermediates in chemical reactions (Molines & Wakselman, 1987). Moreover, it is involved in 1,3-dipolar cycloadditions and sigmatropic rearrangements, producing CF3-substituted pyrazoles (Gladow, Doniz‐Kettenmann, & Reissig, 2014) .

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