352-24-9 | Ethyl 4,4-difluoroacetoacetate

CAS:352-24-9 | Ethyl 4,4-difluoroacetoacetate ,Description

Ethyl 4,4-difluoroacetoacetate (DFA) is a versatile chemical compound with a wide range of applications in the fields of biochemistry, pharmacology, and toxicology. It is a synthetic compound that can be used to synthesize other compounds with pharmaceutical and industrial applications. DFA has been used in the synthesis of various drugs, such as the anticonvulsant drug lamotrigine, and has been studied extensively for its potential therapeutic applications. 
 

Scientific Research Applications

1. Toxicokinetics and Metabolism Analysis

Studies have explored the toxicokinetic properties of similar ethyl compounds and their metabolites, offering insights into how such substances are absorbed, metabolized, and excreted by the human body. For instance, Nihlen, Löf, and Johanson (1998) investigated the uptake, disposition, and respiratory exhalation of ethyl tert-butyl ether (ETBE), a compound structurally related to Ethyl 4,4-difluoroacetoacetate, during controlled exposure in male volunteers. They observed that the kinetic profile of ETBE could be described by distinct phases in blood and urine, suggesting a complex metabolic pathway (Nihlen, Löf, & Johanson, 1998).

2. Application in Plant Growth Regulation

Ethyl compounds like 1-Methylcyclopropene (1-MCP), which can inhibit ethylene action in plants, have been extensively researched for their ability to prevent ethylene effects in fruits, vegetables, and floricultural crops. Studies by Blankenship and Dole (2003) highlight that 1-MCP can help scientists make significant advances in understanding the role of ethylene in plants, indicating a potential area where Ethyl 4,4-difluoroacetoacetate might find application (Blankenship & Dole, 2003).

3. Utility in Analytical Chemistry

Research has demonstrated the utility of certain ethyl compounds in analytical chemistry. For instance, studies on ethyl glucuronide, a direct metabolite of ethanol, have revealed its potential as a stable marker in hair for detecting and quantifying alcohol consumption over long periods (Crunelle et al., 2014). This highlights the potential role of Ethyl 4,4-difluoroacetoacetate in similar analytical applications.

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