353-83-3 | 1,1,1-Trifluoro-2-iodoethane

CAS:353-83-3 | 1,1,1-Trifluoro-2-iodoethane ,Description

1,1,1-Trifluoro-2-iodoethane (TFI) is a synthetic compound that has a wide range of applications in the scientific and industrial fields. It is a colorless and volatile liquid that is used in a variety of chemical reactions, including the synthesis of new compounds, the production of pharmaceuticals, and the modification of existing compounds. TFI is also used as a reagent in organic chemistry, as a solvent for certain compounds, and as a catalyst for certain reactions. In addition, TFI has been used in the production of certain drugs, such as antifungals, antibiotics, and anti-cancer drugs.
 

Scientific Research Applications

• Catalyst in Organic Synthesis

  • 1,1,1-Trifluoro-2-iodoethane has been used as a catalyst in the preparation of α-tosyloxyketones from ketones, showing effective results in good yields. This involves an oxidation process to create a hypervalent iodine intermediate which then reacts with ketones (Zhang et al., 2014) .

• Synthesis of Difluoroallenes

  • It has been used in the synthesis of 1,1-Difluoroallenes, an important compound in various chemical reactions. This process involves zinc-promoted 1,2-elimination and has been deemed efficient for creating these compounds (Oh, Fuchibe & Ichikawa, 2011).

• Photocatalysis Applications

  • In photocatalysis, 1,1,1-Trifluoro-2-iodoethane has been utilized in reactions with alkylalkenes and silyl enol ethers under visible light. This process introduces a trifluoroethyl group and an iodine atom, which is significant for synthesizing β-trifluoromethyl ketones (Huang et al., 2015).

• Cross-Coupling Reactions in Chemistry

  • The compound has found applications in cross-coupling reactions with aryl and heteroaryl boronic acid esters. This protocol allows the introduction of trifluoroethyl groups into a variety of aryl and heteroaryl moieties under mild conditions, which is pivotal in organic synthesis (Liang et al., 2012).

• Trifluoroethylation and Difunctionalization

  • It has been used for the trifluoroethylation of styrenes, a process where a trifluoromethyl group and a hydroxyl group are introduced simultaneously. This radical reaction is significant for generating γ-trifluoromethyl alcohols (Li et al., 2015).

• Synthesis of Fluorinated Organic Compounds

  • A heterobifunctional fluoroalkylation reagent derived from 1,1,1-Trifluoro-2-iodoethane has been developed, proving to be versatile for the preparation of various fluorinated organic compounds (Dai et al., 2016).

• Atmospheric Lifetime Estimation

  • Research has been conducted to estimate the atmospheric lifetimes of compounds like 1,1,1-Trifluoro-2-iodoethane, crucial for understanding their environmental impact (Nakano, Shibata & Watanabe, 2017).

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