354-08-5 | Bromodifluoroacetic acid

CAS:354-08-5 | Bromodifluoroacetic acid ,Description

Bromodifluoroacetic acid (BDFA) is a halogenated organic compound that has been widely used in scientific research for its versatility and effectiveness. It has a wide range of applications in biochemistry, physiology, and other scientific fields. 
 

Scientific Research Applications

Copper-Catalyzed N-Formylation of Amines

Bromodifluoroacetic acid derivatives, like Ethyl bromodifluoroacetate (BrCF2COOEt), have been used in copper-catalyzed N-formylation of amines. This process facilitates the smooth formation of N-formamides from a range of primary, secondary, cyclic arylamines, and aliphatic amines (Li et al., 2018).

Reformatskii-type Syntheses

Chlorodifluoroacetic acid, a close relative of bromodifluoroacetic acid, has shown potential in Reformatskii-type syntheses of fluorine-containing molecules. This offers an attractive extension to the more expensive bromodifluoroacetic acid (Lang & Schaub, 1988).

Triple Mode of Alkylation

Ethyl bromodifluoroacetate has been explored for its triple mode of chemical reactivity. It's used as a difluorocarbene precursor for difluoromethylation of soft nucleophiles and shows divergent reactivity based on nucleophilicity and the base used (Polley et al., 2018).

Pd-Catalyzed Difluoromethylation

Bromodifluoroacetate is utilized in palladium-catalyzed difluoromethylation of aryl boronic acids. This reaction is significant for drug discovery and development due to its high efficiency and compatibility with various functional groups (Feng et al., 2016).

Synthesis of Difluorinated Pseudopeptides

Bromodifluoroacetate derivatives have been used in the Ugi reaction for preparing difluorinated pseudopeptides, showing the compound's utility in synthesizing complex fluorine-containing molecules (Gouge et al., 2004).

Catalytic Distillation Processes

Bromodifluoroacetic acid synthesis technology has been improved through catalytic distillation processes, enhancing the purity and yield of the product (Lupachev et al., 2019).

Deoxytrifluoromethylation of Alcohols

Phenyl bromodifluoroacetate, a derivative of bromodifluoroacetic acid, has been employed in the Cu-catalyzed deoxytrifluoromethylation of alcohols. This method is useful for medicinal, agricultural, and material chemists (de Azambuja et al., 2019).

Effect on Haloacetic Acid Speciation

Studies on the effect of bromide ion on the distribution of haloacetic acid species in the chlorination and chloramination of waters containing aquatic humic substances have utilized bromodifluoroacetic acid (Cowman & Singer, 1996).

Rhodium-Catalyzed Reformatsky-type Reaction

Ethyl bromodifluoroacetate has been used in the Rhodium-catalyzed Reformatsky-type reaction for the synthesis of β-hydroxy-α,α-difluoro carboxylic acid ethyl esters (Sato et al., 2004).

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