354-38-1 | Trifluoroacetamide

CAS:354-38-1 | Trifluoroacetamide ,Description

Trifluoroacetamide (TFA) is a powerful, versatile, and widely used chemical reagent in organic synthesis, biochemistry, and analytical chemistry. TFA is a highly reactive, colorless liquid with a boiling point of 168°C and a molecular weight of 115.05 g/mol. It is an important building block for the synthesis of various organic compounds and has been used in the production of pharmaceuticals, agrochemicals, and other fine chemicals. TFA has also been used as a solvent in the extraction of proteins and other biomolecules.
 

Scientific Research Applications

Perovskite Material Enhancement

Trifluoroacetamide (TFAA) has been recognized for its potential in enhancing perovskite materials. A study highlighted its use in an additive strategy to passivate defect sites in these materials. Specifically, TFAA, with its C═O, −NH2, and F groups, is incorporated into the perovskite precursor solution. This incorporation aims to alleviate defect densities from the source, thereby obtaining high-quality perovskite material, which is crucial for various technological applications, including solar cells and optoelectronic devices​[“] ​.

Stereochemical Analysis

The conformational properties of tertiary trifluoroacetamides have been the subject of scientific inquiry. In one study, dibenzoazepine and benzodiazepine derivatives of trifluoroacetamide, existing as equilibrated E- and Z-amide conformers in solution, were analyzed. This analysis was conducted using 1H and 19F NMR spectroscopy. Understanding these properties is essential for comprehending the chemical behavior and potential applications of trifluoroacetamide derivatives in various fields, including pharmaceuticals and materials science​[“] ​.

Catalyst in Polymer Synthesis

Trifluoroacetamide has been utilized in the synthesis of novel difunctional benzoxazine with o-trifluoroacetamide functionality. This synthesis involves Mannich condensation and is confirmed through various spectroscopy methods. The resultant compound undergoes ring-opening polymerization, indicating trifluoroacetamide's role as a smart latent catalyst. This application is significant in the field of polymer chemistry, where precise control over the polymerization process is crucial for developing materials with desired properties​[“] ​.

Electrolyte Additive in Energy Storage

In the realm of energy storage, particularly concerning lithium anodes, trifluoroacetamide derivatives have been proposed as electrolyte additives. N,O-bis(trimethylsilyl)trifluoroacetamide, for example, is suggested to stabilize the solid electrolyte interface, addressing the issue of lithium dendrites which limit practical application. This application is crucial in improving the safety and efficiency of lithium-based batteries, which are central to many modern technologies​[“] ​.

Organic Synthesis

Trifluoroacetamide is employed as an alternative in the Gabriel synthesis of primary amines from halides. This involves N-alkylation followed by cleavage of the trifluoroacetyl group. It's also used for improved N-alkylation under phase-transfer conditions, allowing successive alkylation with different alkyl groups. This versatility in organic synthesis highlights its significance in creating various chemical compounds, which can have wide-ranging applications in pharmaceuticals, agrochemicals, and materials science​[“] ​.

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