356-27-4 | Ethyl heptafluorobutyrate

CAS:356-27-4 | Ethyl heptafluorobutyrate ,Description

Ethyl heptafluorobutyrate (EHFB) is a fluorinated organic compound that is used in a variety of applications, including as a solvent and in the synthesis of pharmaceuticals. It has a variety of biochemical and physiological effects, and is of particular interest to scientists due to its unique properties. 
 

Scientific Research Applications

• Chemical Derivatization in Analytical Techniques:
  • Ethyl heptafluorobutyrate is used as a derivatizing agent in analytical methods. For example, in the determination of ethyl glucuronide in hair samples, heptafluorobutyric anhydride (HFBA) is employed for derivatization (Agius et al., 2010). This enhances the detection of ethyl glucuronide, a marker for chronic alcohol consumption.
  • Similarly, HFBA is utilized in the analysis of catecholamines, offering improved sensitivity and GLC properties (Sakauchi, Kumaoka, & Hanawa, 1972).
• Biological Fluid Analysis:
  • It has been applied in the chromatographic determination of amines in biological fluids, particularly for monitoring isocyanates and amines. The use of HFBA as a derivatization reagent is highlighted for its effectiveness (Skarping et al., 1989).
• Material Science and Engineering:
  • In the field of energy storage and conversion, ethyl heptafluorobutyrate derivatives, such as ethyl 4,4,4-trifluorobutyrate, have been investigated for their role in improving the performance of lithium-ion batteries (Kim et al., 2018). This derivative helps in stabilizing the interface structure of Ni-rich cathodes and graphite anodes.
• Environmental and Chemical Engineering:
  • Ethyl heptafluorobutyrate is relevant in studies focusing on liquid-liquid phase interactions and separations. For instance, its derivatives have been examined in the context of hydrocarbon separations, particularly in the extraction and purification processes (Arce et al., 2008).
• Forensic Science:
  • In forensic science, derivatives of ethyl heptafluorobutyrate are used for the analysis of substances like fatty acid ethyl esters in hair, which are markers for alcohol consumption (Auwärter et al., 2001) . This aids in the investigation of alcohol abuse cases.
• Pharmaceutical and Clinical Research:
  • It also finds application in the pharmaceutical field, particularly in the analysis of oral fluids for amphetamines and cathinones. HFBA, in this context, serves as a derivatizing agent, facilitating the detection of these compounds (Mohamed & Bakdash, 2017).

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