359-13-7 | 2,2-Difluoroethanol

CAS:359-13-7 | 2,2-Difluoroethanol ,Description

2,2-Difluoroethanol, also known as 2,2-difluoroethanol or 2,2-difluoroethyl alcohol, is an organic compound with the chemical formula C2H4O2F2. It is a colorless, volatile liquid with a sharp, sweet odor. It is used as a solvent in many industrial and laboratory applications and has been studied for its potential medical applications.
 

Scientific Research Applications

• Synthesis and Yield Optimization: Luo Mengfei (2012) highlighted that using low temperature and ethanol as a solvent for 2,2-difluoroethanol synthesis results in a high yield of 98.1%, indicating its efficiency in synthesizing 2,2-difluoroethanol from ethyl difluoroacetate (Luo Mengfei, 2012).
• Surface Chemistry: The study by J. Vaynberg and L. Ng (2005) explored the surface chemistry of 2,2-difluoroethanol on Al2O3, revealing its adsorption and decomposition, which form fluorinated surface ethoxide and surface acetate under different conditions (Vaynberg & Ng, 2005).
• Method for Synthesizing 2,2-Difluoro-3-Hydroxyacids: A method by O. Jiménez et al. (2005) for synthesizing 2,2-difluoro-3-hydroxyacids using hexafluoro-2-propanol as a fluorine source was found to provide good to excellent yields under mild conditions, showcasing a new, mild, and efficient approach (Jiménez, Bosch, & Guerrero, 2005) .
• Vibrational Spectra Analysis: M. Perttilä (1979) analyzed the vibrational spectra of 2,2-difluoroethanol and its OD deuterated analogues, revealing fundamental frequencies in argon and nitrogen matrices (Perttilä, 1979) .
• Industrialized Production Methodology: Yan Zong-gang (2010) discussed the catalytic hydrogenation of difluoroacetyl chloride as a suitable starting material for the industrialized production of 2,2-difluoroethanol, due to its simple reaction conditions and satisfactory yield (Yan Zong-gang, 2010).
• Global Warming Potential Analysis: A study by S. R. Sellevåg et al. (2004) evaluated the global warming potentials of 2-fluoroethanol, 2,2-difluoroethanol, and 2,2,2-trifluoroethanol, finding them to be insignificant compared to CFC-11 (CCl3F), a common ozone-depleting substance (Sellevåg et al., 2004) .
• Atmospheric Degradation Pathways: N. K. Gour et al. (2019) investigated the atmospheric degradation pathways of 2,2-difluoroethanol with Cl atom, highlighting its impact on the chemical's lifetime and global warming potential (Gour et al., 2019).
• Thermodynamic Properties: R. Malhotra and L. Woolf (1995) studied the thermodynamic properties of liquid 2,2-difluoroethanol, discovering it to be significantly less compressible than 2,2,2-trifluoroethanol (Malhotra & Woolf, 1995).

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