360-95-2 | 4-(Trifluoroacetyl)morpholine

CAS:360-95-2 | 4-(Trifluoroacetyl)morpholine ,Description

4-(Trifluoroacetyl)morpholine (TFAM) is a small molecule that has been used in a variety of scientific applications. It is a fluorinated derivative of morpholine, an organic compound composed of a five-membered ring with an oxygen atom and a nitrogen atom at opposite ends. TFAM is a colorless liquid at room temperature and is soluble in water and organic solvents. It is widely used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. In addition, TFAM has been used in the study of biochemical and physiological effects, and its application in laboratory experiments has been investigated. 
 

Scientific Research Applications

Chemical Synthesis

4-(Trifluoroacetyl)morpholine plays a role in chemical synthesis. For instance, it has been utilized in the one-pot, four-component synthesis of dihydropyrano[2,3-c]pyrazoles, offering moderate to excellent yields without the need for chromatographic purification or environmentally hazardous solvents (Zhou, Li, & Su, 2016). Similarly, morpholine triflate, a related compound, is employed as an efficient catalyst in the organocatalytic direct C3 alkenylation of indoles (Xiang, Zhang, Zhang, Cui, & Jiao, 2011).

Pharmaceutical Research

In pharmaceutical research, morpholine derivatives, including those related to 4-(Trifluoroacetyl)morpholine, have been explored for their potential as drug candidates. For example, compounds like 3-oxabicyclo[4.1.0]heptane, a non-nitrogen containing morpholine isostere, have been developed as inhibitors in the PI3K-AKT-mTOR pathway (Hobbs et al., 2019). Morpholine derivatives also exhibit activity against various fungi pathogenic to plants and animals (Polak, 1988).

Biodegradability and Toxicity Studies

Studies on the biodegradability and toxicity of morpholine derivatives have been conducted to understand their environmental impact and safety. A study on 4-benzyl-4-methylmorpholinium-based ionic liquids, which are related to 4-(Trifluoroacetyl)morpholine, revealed insights into their physicochemical properties, cytotoxicity, oral toxicity, and biodegradability (Pernak, Borucka, Walkiewicz, Markiewicz, Fochtman, Stolte, Steudte, & Stepnowski, 2011).

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