371-26-6 | Ethyl 4,4,4-trifluorobutyrate

CAS:371-26-6 | Ethyl 4,4,4-trifluorobutyrate ,Description

Ethyl 4,4,4-trifluorobutyrate, also known as TFBE, is a versatile and important compound in the chemical industry. It is used in a variety of applications, including as a solvent, a reagent, and as a fuel additive. It is also used in the synthesis of pharmaceuticals, agrochemicals, and other industrial products. TFBE has a low vapor pressure and a low boiling point, making it an ideal choice for applications that require a low-temperature reaction environment. In addition, TFBE has a low toxicity and can be safely handled in the laboratory.
 

Scientific Research Applications

Dual-Function Additive in Battery Technology

Ethyl 4,4,4-trifluorobutyrate (ETFB) has been utilized as a dual-function additive to stabilize the interface structure of Ni-rich layered cathodes and graphite anodes in battery cells. It helps in constructing protective layers on both electrodes, significantly enhancing the capacity retention and discharge capacity of these cells. This application is crucial in improving the performance and longevity of batteries, particularly in high-temperature conditions (Kim et al., 2018).

Building Block for Enantiopure Chirons

ETFB has been used as a powerful building block for creating enantiopure chirons. These chirons are significant in the synthesis of trifluoromethyl-β-amino acid series, highlighting ETFB's role in creating complex, optically pure compounds (Michaut et al., 2007).

Role in Stereospecific Synthesis

The compound plays a key role in the highly stereoselective synthesis of α-hydroxy carbonyl compounds. This property is crucial for the development of specific stereochemical configurations in organic synthesis (Morizawa et al., 1986) .

Cycloaddition Reactions

ETFB undergoes regio- and stereospecific cycloaddition with metallo-azomethine ylides, leading to the synthesis of trifluoromethylpyrrolidines. This demonstrates its utility in creating structurally diverse molecules, which is essential in synthetic chemistry (Bonnet-Delpon et al., 2010) .

Precursor for Trifluoromethyl Heterocycles

It serves as a versatile intermediate for synthesizing a wide range of trifluoromethyl heterocycles. This application is significant in the field of organic chemistry for creating compounds with potential pharmaceutical and agrochemical applications (Honey et al., 2012).

Enantioselective Baker’s Yeast Reduction

ETFB is used in enantioselective Baker’s yeast reduction processes. This application is vital in obtaining optically pure compounds, which are essential in various areas of chemistry and pharmaceuticals (Davoli et al., 1999).

Industrial Preparation of Trifluoromethyl Ketones

ETFB is utilized in the industrial preparation of various trifluoromethyl ketones and derivatives. Its use in synthesizing complex fluorinated compounds is highly valuable in organic synthesis (Michel, 2004).

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