371-62-0 | 2-Fluoroethanol

CAS:371-62-0 | 2-Fluoroethanol ,Description

2-Fluoroethanol, also known as 2-Fluoroethanol, is an organic compound with the chemical formula C2H5OH. It is an important intermediate in the synthesis of many organic compounds and has numerous applications in scientific research. It is a colorless liquid with a sweet odor, slightly soluble in water, and miscible with organic solvents. It is used in the synthesis of pharmaceuticals, in the production of perfumes, and as a solvent in organic synthesis.
 

Scientific Research Applications

• Radiopharmaceutical Research: It is used as a model system for studying the autoradiolytic dehalogenation of the radiopharmaceutical drug 2-[18F]fluorodeoxyglucose ([18F]FDG) (Brinkevich et al., 2020).
• Surface Chemistry: In the presence of ferroelectric BaTiO3, 2-Fluoroethanol reacts to produce acetaldehyde, ethylene, and adsorbed fluorine atoms. The activation energy for these reactions varies based on the orientation of the ferroelectric dipoles (Zhao, Bonnell, & Vohs, 2009).
• Molecular Structure Studies: Studies on its molecular structure reveal that the most stable rotamer in 2-Fluoroethanol allows close approach of fluorine and hydrogen atoms, suggesting a hydrogen-fluorine interaction (Buckton & Azrak, 1970).
• IR-Laser Chemistry: 2-Fluoroethanol has been studied using IR-laser chemistry to understand photorotamerization processes when isolated in low-temperature inert gas matrices (Schrems, 1985).
• Intramolecular Hydrogen Bonding: Research indicates that 2-Fluoroethanol predominantly exists in the gauche conformation, where hydroxyl and fluorine are gauche to one another, due to a strong intramolecular hydrogen bond between the fluorine atom and the hydroxyl proton (Griffith & Roberts, 1974).
• Raman Spectroscopy: The Raman spectra of 2-Fluoroethanol show evidence for trans conformers in the liquid phase, contributing to the understanding of conformational energies (Davenport & Schwartz, 1978).
• Diffusion Studies: Its self-diffusion coefficients, similar to those of 1-propanol, suggest more stable hydrogen-bonded structures. This is inferred from its temperature-dependent diffusion characteristics (Gross, Karger, & Price, 1998).
• Toxicology: 2-Fluoroethanol is known to be toxic to rats and causes a rise in tissue concentrations of citrate, indicating its biological impact (Krebs & Eggleston, 1962).

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