Purchase CAS:372-30-5,view related peer-reviewed papers,technical documents,similar products,MSDS & more. Ethyl 3-hydroxy-4,4,4-trifluorobutyrate (ETHF) is a compound that has been studied for its potential applications in scientific research. ETHF is a synthetic organic compound that is composed of three carbon atoms and four fluorine atoms. ETHF is a colorless, non-volatile liquid that is soluble in water and organic sol...
Ethyl 3-hydroxy-4,4,4-trifluorobutyrate (ETHF) is a compound that has been studied for its potential applications in scientific research. ETHF is a synthetic organic compound that is composed of three carbon atoms and four fluorine atoms. ETHF is a colorless, non-volatile liquid that is soluble in water and organic solvents. ETHF has a low vapor pressure and is relatively stable under normal conditions.
Scientific Research Applications
Stereochemical Studies and Synthesis
Stereochemistry in Synthesis: Ethyl 3-hydroxy-4,4,4-trifluorobutyrate is utilized in stereochemical studies, specifically in highly stereoselective synthesis. For example, its reaction with enolates and subsequent reduction processes demonstrate preference for certain stereochemical outcomes, highlighting its role in understanding and controlling stereochemistry in organic synthesis (Morizawa, Yasuda, & Uchida, 1986) .
Battery Technology
Battery Technology: This compound is employed as an additive in battery technology, particularly in stabilizing the interface structure of Ni-rich layered cathodes and graphite anodes in batteries. Its bifunctional nature helps in constructing protective layers on both electrodes, enhancing battery performance and stability (Kim et al., 2018).
Biocatalysis
Biocatalysis Applications: Ethyl 3-hydroxy-4,4,4-trifluorobutyrate can be prepared enantiomerically enriched using biocatalysts like Candida parapsilosis, demonstrating its significance in biocatalysis for producing optically pure compounds. This showcases the potential of biocatalysis in synthesizing complex molecules with high optical purity and yield (Venkataraman & Chadha, 2015).
Enzymatic Reduction
Enzymatic Reduction Studies: Research involving enzymatic reduction of ethyl 3-hydroxy-4,4,4-trifluorobutyrate, particularly using Baker’s yeast, contributes to the understanding of enzyme-substrate interactions and the influence of additives on these reactions. Such studies are vital for the development of enzymatic processes in organic synthesis (Davoli, Forni, Moretti, Prati, & Torre, 1999).
Fluorine Chemistry
Fluorine Chemistry: The compound is investigated in fluorine chemistry for its potential as a precursor in the synthesis of fluorine- and sulfur-containing CH-acids. This highlights its role in the development of new fluorinated compounds, which are important in pharmaceuticals and agrochemicals (Teplenicheva, Kolomiets, & Fokin, 1997) .
Multicomponent Reactions
Multicomponent Reactions: It's used in one-pot, multicomponent reactions for synthesizing complex organic compounds. This illustrates its utility in organic synthesis, enabling efficient and novel routes to synthesize diverse organic structures (Li et al., 2014).
Asymmetric Hydrogenation
Asymmetric Hydrogenation: Research on asymmetric hydrogenation of related compounds demonstrates the potential of ethyl 3-hydroxy-4,4,4-trifluorobutyrate in the synthesis of enantiomerically enriched compounds, an important aspect in pharmaceutical synthesis (Kuroki, Asada, & Iseki, 2000).
Microfluidic Chip Reactor Studies
Microfluidic Chip Reactor Applications: Its derivatives are utilized in the development of microfluidic chip reactors for the stereoselective synthesis of pharmaceutical intermediates. This application underscores the compound's role in innovative chemical process technologies (Kluson et al., 2019).
Palladium Cross-Coupling Reactions
Palladium Cross-Coupling: The compound is used in palladium-catalyzed cross-coupling reactions, a fundamental technique in modern synthetic organic chemistry. This underscores its importance in the synthesis of complex organic molecules (Prié et al., 2003) .
Hydrogenation Studies
Hydrogenation Studies: Research on the hydrogenation of similar compounds offers insights into reaction mechanisms and conditions influencing the production of high-purity compounds, which is crucial in chemical synthesis (Meng, Zhu, & Zhang, 2008).