372-31-6 | Ethyl 4,4,4-trifluoroacetoacetate
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Ethyl 4,4,4-trifluoroacetoacetate (ETFA) is a versatile chemical compound that has a wide range of uses in scientific research and laboratory experiments. It is a colorless liquid that is soluble in organic solvents and has a distinct odor. ETFA is an important reagent in organic synthesis, used in the preparation of a...
CAS:372-31-6 | Ethyl 4,4,4-trifluoroacetoacetate ,Description
Ethyl 4,4,4-trifluoroacetoacetate (ETFA) is a versatile chemical compound that has a wide range of uses in scientific research and laboratory experiments. It is a colorless liquid that is soluble in organic solvents and has a distinct odor. ETFA is an important reagent in organic synthesis, used in the preparation of a variety of compounds, including pharmaceuticals, agrochemicals, and dyes. It is also used to catalyze a variety of reactions, as well as in the synthesis of polymers. In addition, ETFA is a useful intermediate in the production of fluorinated compounds.
Scientific Research Applications
- Building Block for Enantiopure Chirons: ETFAA can be transformed into enantiopure chirons, which have both a trifluoromethyl group and an amino moiety. This process enables the creation of a series of trifluoromethyl-amino acids, crucial for pharmaceutical synthesis (Michaut, Metz, Paris, & Plaquevent, 2007).
- Addition of Thiols and Aminothiols: Ethyl 4,4,4-trifluorocrotonate, a derivative of ETFAA, reacts with thiols and aminothiols to yield 3-thiolation products. Such reactions are significant in the synthesis of sulfur-containing organic compounds (Karimova, Glazkov, Ignatenko, & Kolomiets, 2003).
- Synthesis of Trifluoromethylated Heterocyclic Compounds: ETFAA is used for synthesizing trifluoromethylated heterocyclic compounds under mild conditions. These compounds have potential applications in pharmaceuticals and other industries (朱仕正 et al., 2009) .
- Chemoselective Reactions with Anilines: Ethyl 4,4,4-trifluoroacetoacetate reacts with anilines to produce 2-trifluoromethyl-4- and 4-trifluoromethyl-2 quinolinones. This chemoselectivity is significant for synthesizing complex organic molecules (Berbasov & Soloshonok, 2003).
- Asymmetric Reduction in Organic Media: 1,4-butanediol promotes the asymmetric reduction of ETFAA to (S)-alcohol under water-deficient conditions. This method is useful for producing high-purity chiral alcohols (Zuhse, Leggewie, Hollmann, & Kara, 2015).
- Enantioselective Hydrogenation: ETFAA undergoes enantioselective hydrogenation with cinchona-modified platinum, allowing the synthesis of various trifluoromethyl alcohols with high enantiomeric excess (Arx, Mallát, & Baiker, 2000) .
- Brønsted-Acid-Catalyzed Enantioselective Arylation: ETFAA can undergo enantioselective arylation catalyzed by chiral phosphoric acid, leading to chiral trifluoromethyl compounds. This method is beneficial in asymmetric synthesis (Nie et al., 2009) .
More Information
Product Name : | Ethyl 4,4,4-trifluoro-3-oxobutanoate | ||
CAS No. : | 372-31-6 | Molecular Weight : | 184.11 |
MDL No. : | MFCD00000424 | Purity/ Specification : | |
Molecular Formula : | C6H7F3O3 | Storage : | Sealed in dry,Room Temperature |
Boiling Point : | - |
GHS Pictogram : | |||
Signal Word : | Danger | Precautionary Statements : | P210-P273-P301+P312+P330 |
UN# : | 3272 | Class : | 3 |
Hazard Statements : | H225-H302-H412 | Packing Group : | Ⅲ |